Abcb11 Gene Summary [Rat]
Enables ABC-type xenobiotic transporter activity; bile acid transmembrane transporter activity; and carbohydrate transmembrane transporter activity. Involved in several processes, including canalicular bile acid transport; xenobiotic export from cell; and xenobiotic transmembrane transport. Located in Golgi membrane; intracellular canaliculus; and recycling endosome membrane. Used to study cholestasis. Biomarker of alcoholic hepatitis and cholestasis. Human ortholog(s) of this gene implicated in benign recurrent intrahepatic cholestasis 2; intrahepatic cholestasis; liver cirrhosis; and progressive familial intrahepatic cholestasis 2. Orthologous to human ABCB11 (ATP binding cassette subfamily B member 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Abcb11 |
| Official Name | ATP binding cassette subfamily B member 11 [Source:RGD Symbol;Acc:619930] |
| Ensembl ID | ENSRNOG00000050860 |
| Bio databases IDs | |
| Aliases | ATP binding cassette subfamily B member 11 |
| Synonyms | ABC16, ATP binding cassette subfamily B member 11, ATP-binding cassette, sub-family B member 11, Bile Salt Export Pump, BRIC2, BSEP, Lith1, PFIC-2, PGY4, SPGP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Abcb11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FeS assembly ATPase SufC
- phosphonate ABC transporter, ATP-binding protein
- type I secretion system ABC transporter, PrtD family
- Conjugate Transporter-2 (CT2) Family protein
- nitrate transport ATP-binding subunits C and D
- heme ABC exporter, ATP-binding protein CcmA
- thiol reductant ABC exporter, CydC subunit
- energy-coupling factor transporter ATPase
- xenobiotic-transporting ATPase
- bile acid transporter
- nickel import ATP-binding protein NikE
- canalicular bile acid transporter
- bile acid porter
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
- lipid A export permease/ATP-binding protein MsbA
- carbohydrate transporter
- linker domain
- protein binding
- urea ABC transporter, ATP-binding protein UrtE
- ABC transporter transmembrane region
- Six-transmembrane helical domain of the ATP-binding cassette transporters
- thiol reductant ABC exporter, CydD subunit
- cystic fibrosis transmembrane conductor regulator (CFTR)
- ABC transporter
- ABC transporter, permease/ATP-binding protein
- transporter
Pathways
Biological processes and signaling networks where the Abcb11 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- hepatocellular carcinoma
- primary biliary cirrhosis
- benign recurrent intrahepatic cholestasis 2
- growth failure
- progressive familial intrahepatic cholestasis type 2
- intrahepatic cholestasis of pregnancy type 3
- gout
- hereditary disorder
regulates
- lipid
- taurocholic acid
- bile acid
- taurodeoxycholic acid
- taurochenodeoxycholate
- bile salt conjugates
- cholesterol
- bile salt
- phospholipid
- deoxycholate
role in cell
- accumulation in
- damage
- abnormal morphology
- drug resistance
- transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- membrane fraction
- cell surface
- apical compartment
- intracellular membranes
- cellular membrane
- endosomes
- intercellular junctions
- apical cell surfaces
- apical membrane
- Golgi membrane
- endosomal membrane
- recycling endosomes
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Abcb11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to estrogen stimulus
- transmembrane transport
- drug export
- lipid homeostasis
- response to organic cyclic compound
- bile acid biosynthetic process
- cholesterol homeostasis
- bile acid metabolic process
- fatty acid metabolic process
- phospholipid homeostasis
- response to ethanol
- response to oxidative stress
- regulation of fatty acid beta-oxidation
- drug transmembrane transport
- xenobiotic metabolic process
- carbohydrate transmembrane transport
- canalicular bile acid transport
- protein ubiquitination
- bile acid and bile salt transport
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
- plasma membrane
- cell surface
- intracellular canaliculus
- intercellular canaliculus
- endosome
- extracellular vesicular exosome
- membrane
- recycling endosome
- recycling endosome membrane
- basolateral plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- canalicular bile acid transmembrane transporter activity
- ATP binding
- bile acid transmembrane transporter activity
- bile acid-exporting ATPase activity
- protein binding
- carbohydrate transmembrane transporter activity
- xenobiotic-transporting ATPase activity