Ppara Gene Summary [Rat]
Enables several functions, including MDM2/MDM4 family protein binding activity; NFAT protein binding activity; and enzyme binding activity. Involved in several processes, including behavioral response to nicotine; cellular response to fructose stimulus; and negative regulation of cell growth involved in cardiac muscle cell development. Predicted to be active in nucleus. Used to study hepatocellular carcinoma; hypertension; hypertensive encephalopathy; and periodontitis. Biomarker of alcoholic hepatitis; hydrocephalus; hypertension; obesity; and steatotic liver disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppara |
| Official Name | peroxisome proliferator activated receptor alpha [Source:RGD Symbol;Acc:3369] |
| Ensembl ID | ENSRNOG00000021463 |
| Bio databases IDs | |
| Aliases | peroxisome proliferator activated receptor alpha |
| Synonyms | 4933429D07Rik, AI118064, AW742785, hPPAR, MGC2452, NR1C1, peroxisome proliferator activated receptor alpha, peroxisome proliferator activated receptor α, PPAR, PPAR alpha, PPAR α |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ppara often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PKC phosphorylation site
- transcription regulator
- A-B domain
- steroid hormone receptor
- A/B region
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- transcription factor binding
- AF-2 transcription activation domain
- H helix
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- nuclear receptor ligand binding domain
- AF-1 domain
- ligand-binding domain
- A domain of PPARalpha
- ligand-dependent nuclear receptor
- B domain of PPARalpha
- phosphatase binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- lipid binding
- protein kinase binding
- signaling receptor activity
- DNA binding domain
- nucleic acid binding
- C domain of PPAR-alpha
- enzyme binding
- helical domain
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- binding protein
- double-stranded DNA binding
- hinge domain
- zinc finger domain
- Ligand-binding domain of nuclear hormone receptor
- transcription factor activity
Pathways
Biological processes and signaling networks where the Ppara gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- keratoconjunctivitis sicca
- non-insulin-dependent diabetes mellitus
- biliary tract cancer
- hepatocellular carcinoma
- neoplasia
- liver cancer
- epithelial cancer
- Huntington disease
- epithelial neoplasia
role in cell
- function
- expression in
- proliferation
- apoptosis
- cell death
- growth
- quantity
- production in
- size
- induction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- perinuclear region
- cytosol
- nuclear foci
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ppara gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell growth involved in cardiac muscle cell development
- negative regulation of appetite
- positive regulation of ATP biosynthetic process
- epidermis development
- negative regulation of glycolysis
- negative regulation of cytokine production involved in inflammatory response
- lipoprotein metabolic process
- regulation of circadian rhythm
- positive regulation of transcription from RNA polymerase II promoter
- steroid hormone mediated signaling pathway
- positive regulation of fatty acid metabolic process
- positive regulation of gluconeogenesis
- hormone-mediated signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- heart development
- response to ethanol
- circadian regulation of gene expression
- wound healing
- response to insulin stimulus
- response to hypoxia
- enamel mineralization
- positive regulation of fatty acid oxidation
- cellular response to fructose stimulus
- positive regulation of transcription, DNA-dependent
- intracellular receptor mediated signaling pathway
- gluconeogenesis
- regulation of fatty acid transport
- negative regulation of sequestering of triglyceride
- behavioral response to nicotine
- positive regulation of fatty acid beta-oxidation
- negative regulation of receptor activity
- negative regulation of inflammatory response
- negative regulation of blood pressure
- response to nutrient
- cellular response to starvation
- nitric oxide metabolic process
- fatty acid metabolic process
- positive regulation of lipid biosynthetic process
- cell differentiation
- negative regulation of macrophage derived foam cell differentiation
- negative regulation of cholesterol storage
- regulation of cellular ketone metabolic process
- negative regulation of transforming growth factor beta receptor signaling pathway
- negative regulation of protein kinase B signaling cascade
- regulation of fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phosphatase binding
- zinc ion binding
- protein domain specific binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- lipid binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- transcription coactivator binding
- DNA binding
- ubiquitin conjugating enzyme binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- steroid hormone receptor activity
- mitogen-activated protein kinase kinase kinase binding
- NFAT protein binding