Hax1 Gene Summary [Rat]
Enables protein domain specific binding activity. Predicted to be involved in several processes, including granulocyte colony-stimulating factor signaling pathway; positive regulation of granulocyte differentiation; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in apical plasma membrane; clathrin-coated vesicle; and sarcoplasmic reticulum. Human ortholog(s) of this gene implicated in severe congenital neutropenia 3. Orthologous to human HAX1 (HCLS1 associated protein X-1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hax1 |
| Official Name | HCLS1 associated protein X-1 [Source:RGD Symbol;Acc:727960] |
| Ensembl ID | ENSRNOG00000045647 |
| Bio databases IDs | |
| Aliases | HCLS1 associated protein X-1 |
| Synonyms | HCLS1 associated protein X-1, HCLS1 associated X-1, HCLSBP1, HS1-Associated Protein X-1, HS1BP1, HSP1BP-1, mHAX-1s, SCN3, SIG-111, Silg111 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hax1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding activity, bridging
- protein domain specific binding
- protein binding
- interleukin-1 binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- calcium overload
- hypoplasia
- lung neoplasm
- autosomal recessive severe congenital neutropenia type 3
- adipsia
- hereditary disorder
- breast carcinoma
- severe congenital neutropenia
role in cell
- proliferation
- adhesion
- apoptosis
- expression in
- cell death
- formation
- migration
- binding in
- phosphorylation in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- actin cytoskeleton
- Nucleus
- sarcoplasmic reticulum
- Endoplasmic Reticulum
- Mitochondria
- apical membrane
- cell membrane-lagging edges
- mitochondrial matrix
- mitochondrial intermembrane space
- mitochondrial outer membrane
- nuclear envelope
- cell membrane leading edge
- perikaryon
- clathrin-coated vesicles
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hax1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of actin filament polymerization
- granulocyte colony-stimulating factor signaling pathway
- positive regulation of granulocyte differentiation
- negative regulation of apoptotic process
- cellular response to cytokine stimulus
- regulation of apoptotic process
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of peptidyl-tyrosine phosphorylation
- positive regulation of protein kinase B signaling cascade
- mitochondrion organization
Cellular Component
Where in the cell the gene product is active
- sarcoplasmic reticulum
- cytoplasmic mRNA processing body
- endoplasmic reticulum
- mitochondrial outer membrane
- nuclear envelope
- transcription factor complex
- mitochondrial intermembrane space
- nuclear membrane
- mitochondrial matrix
- cell cortex
- mitochondrion
- actin cytoskeleton
- clathrin-coated vesicle
- apical plasma membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling adaptor activity
- interleukin-1 binding