icon_0328_cc_gen_hmr_bacteria-s

PXR/RXR Activation

The pregnane X receptor (PXR) is a nuclear receptor that is activated by a spectrum of structurally unrelated endogenous compounds and clinical drugs. Expressed predominantly in the liver and intestine, activated PXR in conjunction with the retinoid X receptor (RXR) plays a central role in drug metabolism by inducing the cytochrome P450 family of enzymes. This includes the induction of CYP3A4, an enzyme responsible for the phase I metabolism of more than 50% of drugs in use today. In addition, PXR/RXR activation induces drug conjugation enzymes as well as the drug efflux pumps. Thus, PXR is an important regulator of drug metabolism and excretion...

PXR/RXR Activation

Pathway Summary

The pregnane X receptor (PXR) is a nuclear receptor that is activated by a spectrum of structurally unrelated endogenous compounds and clinical drugs. Expressed predominantly in the liver and intestine, activated PXR in conjunction with the retinoid X receptor (RXR) plays a central role in drug metabolism by inducing the cytochrome P450 family of enzymes. This includes the induction of CYP3A4, an enzyme responsible for the phase I metabolism of more than 50% of drugs in use today. In addition, PXR/RXR activation induces drug conjugation enzymes as well as the drug efflux pumps. Thus, PXR is an important regulator of drug metabolism and excretion. PXR/RXR activation can also regulate several endogenous processes like bile acid synthesis, their metabolism and transport, gluconeogenesis, lipid metabolism and cholesterol homeostasis. Thus the PXR/RXR heterodimer plays a fundamental role by regulating the expression of a critical set of protective gene products involved in xenobiotic and endobiotic metabolism.

PXR/RXR Activation Genes list

Explore Genes related to PXR/RXR Activation

Products related to PXR/RXR Activation

Explore products related to PXR/RXR Activation
GeneGlobe ID: SBHS-056Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Nuclear Receptors & Coregulators
QuantiNova LNA PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: UPHS-056Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Nuclear Receptors & Coregulators
QuantiNova LNA Probe PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: PAHS-180Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Retinoic Acid Signaling
RT2 Profiler PCR Array
Product Specification
Copy Details
GeneGlobe ID: PAHS-056Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Nuclear Receptors & Coregulators
RT2 Profiler PCR Array
Product Specification
Copy Details

Didn't find what you're looking for?

Discover other products relevant to this gene list with our Panel Finder. Check it out.