Ren1

Enables aspartic-type endopeptidase activity. Involved in angiotensin maturation; male gonad development; and mesonephros development. Acts upstream of or within with a positive effect on regulation of blood pressure. Acts upstream of or within several processes, including drinking behavior; hormone-mediated signaling pathway; and renin-angiotensin regulation of aldosterone production. Located in extracellular space. Is active in extracellular region. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and trunk. Human ortholog(s) of this gene implicated in autosomal dominant tubulointerstitial kidney disease; essential hypertension; hand, foot and mouth disease; hypertension; and portal hypertension. Orthologous to human REN (renin). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ren1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.