Spp1 Gene Summary [Mouse]
Enables extracellular matrix binding activity and integrin binding activity. Involved in bone mineralization and calcium ion homeostasis. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; intracellular chloride ion homeostasis; and intracellular monoatomic cation homeostasis. Located in apical part of cell and cytoplasm. Is expressed in several structures, including alimentary system; brain; metanephros; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); and hepatitis. Orthologous to human SPP1 (secreted phosphoprotein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spp1 |
| Official Name | secreted phosphoprotein 1 [Source:MGI Symbol;Acc:MGI:98389] |
| Ensembl ID | ENSMUSG00000029304 |
| Bio databases IDs | |
| Aliases | secreted phosphoprotein 1 |
| Synonyms | 2AR, Apl-1, BNSP, Bone Sialoprotein, Bopn, Bsp, BSPI, Eta, ETA-1, LOC100359743, LOC100503439, NEPHROPONTIN, OP, OPN, OPNI, Opnl, OSP, OST, Osteopontin, OSTP, Ric, secreted phosphoprotein 1, SPP1 isoform 1, UROPONTIN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cryptic epitope
- binding protein
- thrombin cleavage site
- extracellular matrix binding
- integrin binding
- RGD motif
- protein binding
- cytokine
- Osteopontin
- integrin binding domain
Pathways
Biological processes and signaling networks where the Spp1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- epithelial neoplasia
- benign neoplasia
- cancer
- abdominal cancer
- epithelial cancer
- experimental autoimmune encephalomyelitis
- neoplasia
- metastatic breast cancer
- infection
role in cell
- expression in
- binding in
- growth
- differentiation
- glycolysis in
- apoptosis
- chemotaxis
- binding
- activation in
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- perimembrane region
- clear zone
- Cytoplasm
- cell surface
- intracellular space
- apical compartment
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
- basolateral membrane
- ruffled borders
- extracellular matrix
- cellular protrusions
- dendrites
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to vitamin D
- signal transduction
- decidualization
- cell adhesion
- response to steroid hormone stimulus
- androgen catabolic process
- embryo implantation
- cellular response to testosterone stimulus
- positive regulation of estradiol secretion
- positive regulation of transcription, DNA-dependent
- negative regulation of collateral sprouting of intact axon in response to injury
- positive regulation of bone resorption
- osteoblast differentiation
- response to macrophage colony-stimulating factor stimulus
- biomineral tissue development
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- Golgi apparatus
- extracellular region
- cell projection
Molecular Function
What the gene product does at the molecular level
- extracellular matrix binding
- protein binding
- small molecule binding
- integrin binding
- cytokine activity