mt-Co1 Gene Summary [Mouse]
Enables cytochrome-c oxidase activity. Predicted to be involved in aerobic respiration; respiratory electron transport chain; and response to oxidative stress. Part of respiratory chain complex IV. Is active in mitochondrial inner membrane. Is expressed in several structures, including brain; brown fat; liver; musculature; and stomach. Orthologous to human MT-CO1 (mitochondrially encoded cytochrome c oxidase I). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | mt-Co1 |
| Official Name | mitochondrially encoded cytochrome c oxidase I [Source:MGI Symbol;Acc:MGI:102504] |
| Ensembl ID | ENSMUSG00000064351 |
| Bio databases IDs | |
| Aliases | mitochondrially encoded cytochrome c oxidase I |
| Synonyms | Co1, COI, Complex IV Mitochondrial Subunit I, COX1, COX-I, cytochrome c oxidase I, Cytochrome C Oxidase Subunit 1, cytochrome c oxidase subunit I, MT-COI, X57780 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mt-Co1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome-c oxidase
- Cytochrome C and Quinol oxidase polypeptide I
- enzyme
- protein binding
- Heme_Cu_Oxidase_I
Pathways
Biological processes and signaling networks where the Mt-Co1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- migraines
- migraine with aura
- migraine without aura
- Alzheimer disease
- hypertension
- obesity
- bursitis
- prostate cancer
- headache
role in cell
- generation in
- activation
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- insoluble fractions
- mitochondrial fraction
- Mitochondria
- mitochondrial membrane
- mitochondrial inner membrane
- nuclear envelope
- neurites
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mt-Co1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- response to hypoxia
- cerebellum development
- electron transport coupled proton transport
- response to copper ion
- mitochondrial electron transport, cytochrome c to oxygen
- cellular respiration
- response to electrical stimulus
Cellular Component
Where in the cell the gene product is active
- mitochondrial membrane
- respiratory chain complex IV
- mitochondrial respiratory chain complex III
- mitochondrial respiratory chain complex IV
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cytochrome-c oxidase activity
- metal ion binding
- heme binding