Ucp1 Gene Summary [Mouse]
Enables long-chain fatty acid binding activity; oxidative phosphorylation uncoupler activity; and purine ribonucleotide binding activity. Involved in several processes, including cellular response to cold; diet induced thermogenesis; and positive regulation of cold-induced thermogenesis. Acts upstream of or within brown fat cell differentiation and regulation of transcription by RNA polymerase II. Located in mitochondrial inner membrane. Is expressed in several structures, including adipose tissue; adrenal gland; submandibular gland; telencephalon; and thymus. Human ortholog(s) of this gene implicated in hypertension and type 2 diabetes mellitus. Orthologous to human UCP1 (uncoupling protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ucp1 |
| Official Name | uncoupling protein 1 (mitochondrial, proton carrier) [Source:MGI Symbol;Acc:MGI:98894] |
| Ensembl ID | ENSMUSG00000031710 |
| Bio databases IDs | |
| Aliases | uncoupling protein 1 (mitochondrial, proton carrier) |
| Synonyms | LOC100909612, SLC25A7, Thermogenin, UCP, Ucpa, Uncoupling protein 1, uncoupling protein 1 (mitochondrial, proton carrier), Uncp |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ucp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding
- phospholipid binding
- hydrogen ion transporter
- nucleotide binding
- binding protein
- GDP binding
- fatty acid binding
- Mitochondrial carrier protein
- protein binding
- purine nucleotide binding
- transporter
- oxidative phosphorylation uncoupler
Pathways
Biological processes and signaling networks where the Ucp1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- obesity
- non-insulin-dependent diabetes mellitus
- tumorigenesis
- metastasis
- hypothermia
- bronchiolo-alveolar adenocarcinoma
- broncho-alveolar lung cancer
- dyslipidemia
- aldosterone producing adrenocortical adenoma
role in cell
- expression in
- differentiation
- swelling
- depolarization
- hyperpolarization
- transport in
- transmembrane potential
- function
- production in
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial envelope
- Mitochondria
- mitochondrial membrane
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ucp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cold
- brown fat cell differentiation
- response to temperature stimulus
- cellular response to fatty acid
- cellular response to hormone stimulus
- cellular response to cold
- cellular response to reactive oxygen species
- response to nutrient levels
- diet induced thermogenesis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- hydrogen ion transmembrane transporter activity
- transmembrane transporter activity
- long-chain fatty acid binding
- GDP binding
- oxidative phosphorylation uncoupler activity
- purine ribonucleotide binding