Ncf4 Gene Summary [Mouse]
Predicted to enable phosphatidylinositol-3-phosphate binding activity and superoxide-generating NADPH oxidase activator activity. Predicted to be involved in superoxide anion generation. Located in cytoplasm. Is expressed in liver; lower urinary tract; stomach; and testis. Human ortholog(s) of this gene implicated in autosomal recessive chronic granulomatous disease 3 and rheumatoid arthritis. Orthologous to human NCF4 (neutrophil cytosolic factor 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ncf4 |
| Official Name | neutrophil cytosolic factor 4 [Source:MGI Symbol;Acc:MGI:109186] |
| Ensembl ID | ENSMUSG00000071715 |
| Bio databases IDs | |
| Aliases | neutrophil cytosolic factor 4 |
| Synonyms | CGD3, NCF, neutrophil cytosolic factor 4, P40PHOX, SH3PXD4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ncf4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- superoxide-generating NADPH oxidase activator
- enzyme
- The Phox Homology domain, a phosphoinositide binding module
- protein binding
- PB1
- phosphatidylinositol binding
- PX domain
- Phox and Bem1 domain
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Ncf4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cystic fibrosis
- cytochrome b-positive autosomal recessive chronic granulomatous disease type 3
- polyarticular juvenile rheumatoid arthritis
- chronic granulomatous disease
- diffuse systemic sclerosis
- androgenic alopecia
- primary antiphospholipid antibody syndrome
- cardiotoxicity
- multiple sclerosis
role in cell
- activation in
- recruitment
- phosphorylation in
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- phagolysosome
- cytosol
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ncf4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phagocytosis
- respiratory burst
- superoxide anion generation
Cellular Component
Where in the cell the gene product is active
- NADPH oxidase complex
- phagolysosome
- cytoplasm
- membrane
- cytosol
- endosome membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- superoxide-generating NADPH oxidase activator activity
- phosphatidylinositol-3-phosphate binding