Ptgir Gene Summary [Mouse]
Predicted to enable prostacyclin receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; negative regulation of platelet-derived growth factor receptor signaling pathway; and negative regulation of smooth muscle cell proliferation. Acts upstream of or within response to lipopolysaccharide. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; gallbladder; genitourinary system; hemolymphoid system gland; and limb segment. Orthologous to human PTGIR (prostaglandin I2 receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptgir |
| Official Name | prostaglandin I receptor (IP) [Source:MGI Symbol;Acc:MGI:99535] |
| Ensembl ID | ENSMUSG00000043017 |
| Bio databases IDs | |
| Aliases | prostaglandin I receptor (IP) |
| Synonyms | IP, Ipr, ip-receptor, I prostanoid receptor, PGI2, PGI2/PGE1 receptor, PGI2 receptor, PRIPR, prostaglandin I2 receptor, prostaglandin I receptor (IP), prostanoid IP receptor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptgir often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- extracellular domain
- intracellular loop
- CAAX box
- guanyl-nucleotide exchange factor
- transmembrane domain
- extracellular loop
- 7 transmembrane receptor (rhodopsin family)
- prenylation site
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Ptgir gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- thrombosis
- chronic kidney disease
- peripheral arterial disease
- myocardial ischemia
- heart failure
- hypertension
- HIV infection
- non-insulin-dependent diabetes mellitus
- pulmonary hypertensive arterial disease
- heritable pulmonary artery hypertension
role in cell
- proliferation
- production in
- quantity
- transcription in
- number
- aggregation
- fusion
- migration
- activation
- infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cellular membrane
- cytosol
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptgir gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- negative regulation of smooth muscle cell proliferation
- cell-cell signaling
- response to lipopolysaccharide
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- negative regulation of platelet-derived growth factor receptor signaling pathway
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- guanyl-nucleotide exchange factor activity
- prostacyclin receptor activity