Iars Gene Summary [Mouse]
Enables isoleucine-tRNA ligase activity. Involved in isoleucyl-tRNA aminoacylation. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and urinary system. Orthologous to human IARS1 (isoleucyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Iars |
| Official Name | isoleucine-tRNA synthetase [Source:MGI Symbol;Acc:MGI:2145219] |
| Ensembl ID | ENSMUSG00000037851 |
| Bio databases IDs | |
| Aliases | isoleucine-tRNA synthetase |
| Synonyms | 2510016L12RIK, E430001P04RIK, GRIDHH, IARS, Iarsl, ILERS, ILE TRNA SYNTHASE, ILRS, IRS, isoleucyl-tRNA synthetase 1, LOC103690033, OJ, PRO0785 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Iars often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein repeat
- Domain of unknown function (DUF5915)
- enzyme binding
- enzyme
- protein binding
- isoleucine-tRNA ligase
- valyl-tRNA synthetase
- tRNA synthetases class I (I, L, M and V)
- class Ia aminoacyl tRNA synthetases anticodon binding domain
- isoleucyl-tRNA synthetase
- leucyl-tRNA synthetase, eubacterial and mitochondrial family
- Anticodon-binding domain of tRNA ligase
- nucleotidyl transferase superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- growth retardation, intellectual developmental disorder, hypotonia, and hepatopathy
- small cell lung cancer
- cleft palate
- malaria
- severe acute respiratory syndrome
role in cell
- activation in
- transmembrane potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- cytosol
- nucleoplasm
- nuclear scaffolds
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Iars gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- isoleucyl-tRNA aminoacylation
- tRNA aminoacylation for protein translation
- osteoblast differentiation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- membrane
- cytosol
- aminoacyl-tRNA synthetase multienzyme complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- isoleucine-tRNA ligase activity
- GTPase binding
- aminoacyl-tRNA editing activity
- tRNA binding