Nr2c2 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and nuclear receptor activity. Involved in several processes, including p38MAPK cascade; positive regulation of embryonic development; and positive regulation of myoblast differentiation. Acts upstream of or within lipopolysaccharide-mediated signaling pathway; meiotic cell cycle; and spermatogenesis. Predicted to be located in nucleoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human NR2C2 (nuclear receptor subfamily 2 group C member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nr2c2 |
| Official Name | nuclear receptor subfamily 2, group C, member 2 [Source:MGI Symbol;Acc:MGI:1352466] |
| Ensembl ID | ENSMUSG00000005893 |
| Bio databases IDs | |
| Aliases | nuclear receptor subfamily 2, group C, member 2 |
| Synonyms | mKIAA4145, nuclear receptor subfamily 2 group C member 2, nuclear receptor subfamily 2, group C, member 2, TAK1, TR4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nr2c2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- acetylation site
- DNA binding domain
- nucleic acid binding
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- protein binding
- sequence-specific DNA binding
- activation loop
- nuclear receptor ligand binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- ligand-binding domain
- ligand-dependent nuclear receptor
- Ligand-binding domain of nuclear hormone receptor
- transcription factor activity
Pathways
Biological processes and signaling networks where the Nr2c2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- head and neck neoplasia
- epithelial neoplasia
- sickle cell anemia
- mechanical hypersensitivity
- hepatosplenomegaly
- oligozoospermia
- corticotrophic adenoma
- adenoma formation
- head and neck neuroendocrine neoplasia
- obesity
role in cell
- proliferation
- apoptosis
- accumulation
- expression in
- invasion by
- size
- survival
- differentiation
- docetaxel sensitivity
- cell proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
- nuclear envelope
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nr2c2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- spermatogenesis
- anatomical structure development
- cell differentiation
- nervous system development
- regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of embryonic development
- intracellular receptor mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity