Brd4 Gene Summary [Mouse]
Enables several functions, including RNA polymerase II C-terminal domain binding activity; lysine-acetylated histone binding activity; and protein serine/threonine kinase activity. Involved in positive regulation of T-helper 17 cell lineage commitment. Acts upstream of or within chromosome segregation; inner cell mass cell proliferation; and protein autophosphorylation. Located in chromatin and condensed nuclear chromosome. Part of cyclin/CDK positive transcription elongation factor complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; pancreas; and sensory organ. Used to study nephrocalcinosis. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 6; colon cancer; and idiopathic pulmonary fibrosis. Orthologous to human BRD4 (bromodomain containing 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Brd4 |
| Official Name | bromodomain containing 4 [Source:MGI Symbol;Acc:MGI:1888520] |
| Ensembl ID | ENSMUSG00000024002 |
| Bio databases IDs | |
| Aliases | bromodomain containing 4 |
| Synonyms | Brd5, bromodomain containing 4, CAP, CDLS6, FSHRG4, HUNK1, HUNKI, LOC100043433, MCAP, WI-11513 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Brd4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- histone binding
- [RNA-polymerase]-subunit kinase
- transcription co-activator
- degron
- nucleic acid binding
- protein binding activity, bridging
- transcription cofactor
- enzyme binding
- chromatin binding
- p53 binding
- extraterminal domain
- Bromodomain extra-terminal - transcription regulation
- protein binding
- Bromodomain
- sequence-specific DNA binding
- DNA binding
- C-terminal domain of bromodomain protein 4
- kinase
- binding protein
- double-stranded DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- neoplastic cell transformation
- tumorigenesis
- hepatic fibrosis
- Cornelia de Lange syndrome type 6
- pulmonary hypertensive arterial disease
- organismal death
- bladder cancer
- hereditary disorder
role in cell
- migration
- expression in
- apoptosis
- proliferation
- quantity
- number
- phosphorylation in
- activation
- activation in
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromosome
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Brd4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- positive regulation of transcription, DNA-dependent
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- regulation of inflammatory response
- positive regulation of T-helper 17 cell lineage commitment
- chromatin organization
- response to DNA damage stimulus
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- positive regulation of G2/M transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- condensed nuclear chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- p53 binding
- transcription cofactor activity
- protein binding
- transcription coactivator activity
- RNA polymerase II carboxy-terminal domain kinase activity
- histone acetyl-lysine binding
- transcription regulatory region sequence-specific DNA binding
- chromatin binding
- enzyme binding