Nme4 Gene Summary [Mouse]
Predicted to enable cardiolipin binding activity and nucleoside diphosphate kinase activity. Predicted to be involved in lipid transport. Located in mitochondrion. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and trigeminal ganglion. Orthologous to human NME4 (NME/NM23 nucleoside diphosphate kinase 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nme4 |
| Official Name | NME/NM23 nucleoside diphosphate kinase 4 [Source:MGI Symbol;Acc:MGI:1931148] |
| Ensembl ID | ENSMUSG00000024177 |
| Bio databases IDs | |
| Aliases | NME/NM23 nucleoside diphosphate kinase 4 |
| Synonyms | 2610027N22Rik, 2810024O08Rik, 5730493H09Rik, LOC682382, NDK, NDPK-D, NM23D, NM23H4, NM23-M4, NME/NM23 nucleoside diphosphate kinase 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nme4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- phospholipid binding
- nucleoside diphosphate kinase
- Nucleoside diphosphate kinase family
- binding protein
- NDPk
- enzyme binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- hepatic steatosis
- Rett syndrome
- mucoepidermoid carcinoma
role in cell
- apoptosis
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial intermembrane space
- mitochondrial outer membrane
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nme4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid transport
- UTP biosynthetic process
- CTP biosynthetic process
- GTP biosynthetic process
- nucleoside metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial intermembrane space
- mitochondrial matrix
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- nucleoside diphosphate kinase activity