Tshz2 Gene Summary [Mouse]
Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within regulation of gene expression. Predicted to be active in nucleus. Is expressed in several structures, including forelimb; genitourinary system; heart valve; limb bud; and telencephalon. Orthologous to human TSHZ2 (teashirt zinc finger homeobox 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tshz2 |
| Official Name | teashirt zinc finger family member 2 [Source:MGI Symbol;Acc:MGI:2153084] |
| Ensembl ID | ENSMUSG00000047907 |
| Bio databases IDs | |
| Aliases | teashirt zinc finger family member 2 |
| Synonyms | 2900073F20RIK, B830045G17, C20ORF17, LOC100288461, LOC100292165, mKIAA4248, Mtsh2, OVC10-2, Sdccag33l, teashirt2, teashirt zinc finger family member 2, teashirt zinc finger homeobox 2, TSH2, ZABC2, Zfp218, ZNF218 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tshz2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- protein binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- head and neck squamous cell carcinoma
- lung squamous cell carcinoma
- squamous cell lung cancer
- Alzheimer disease
- sarcoidosis
- urothelial bladder carcinoma
- transitional cell bladder cancer
- non-insulin-dependent diabetes mellitus
- HER2 negative hormone receptor negative breast cancer
- renal clear cell adenocarcinoma
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tshz2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- metal ion binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity