Tshz3 Gene Summary [Mouse]
Predicted to enable DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and chromatin binding activity. Involved in several processes, including positive regulation of synaptic transmission; regulation of respiratory gaseous exchange by nervous system process; and smooth muscle tissue development. Acts upstream of or within several processes, including kidney development; positive regulation of smooth muscle cell differentiation; and sensory perception of touch. Located in mitochondrion. Is expressed in genitourinary system and peripheral nervous system. Used to study autism spectrum disorder. Orthologous to human TSHZ3 (teashirt zinc finger homeobox 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tshz3 |
| Official Name | teashirt zinc finger family member 3 [Source:MGI Symbol;Acc:MGI:2442819] |
| Ensembl ID | ENSMUSG00000021217 |
| Bio databases IDs | |
| Aliases | teashirt zinc finger family member 3 |
| Synonyms | A630038G13Rik, KIAA1474, mKIAA1474, teashirt3, teashirt zinc finger family member 3, teashirt zinc finger homeobox 3, TSH3, Zfp537, ZNF537 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tshz3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- chromatin binding
- protein binding
- zinc finger domain
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- acute myeloid leukemia
- non-insulin-dependent diabetes mellitus
- breast adenocarcinoma
- pervasive developmental disorder
- tumorigenesis
- autism-like behavioral deficit
- urothelial bladder carcinoma
- transitional cell bladder cancer
- chronic obstructive pulmonary disease
role in cell
- expression in
- upregulation in
- cell death
- binding in
- differentiation
- repression in
- downregulation in
- recruitment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Plasma Membrane
- nucleoplasm
- growth cone
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tshz3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- long-term synaptic potentiation
- positive regulation of synaptic transmission, glutamatergic
- regulation of respiratory gaseous exchange by neurological system process
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- growth cone
- nucleus
- chromatin
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- metal ion binding
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity