Spop Gene Summary [Mouse]
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Acts upstream of or within several processes, including glucose homeostasis; positive regulation of apoptotic process; and regulation of DNA-templated transcription. Located in nuclear speck. Is expressed in cerebral cortex ventricular layer; cortical plate; lung; metanephros; and pancreas. Human ortholog(s) of this gene implicated in colorectal cancer; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human SPOP (speckle type BTB/POZ protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spop |
| Official Name | speckle-type BTB/POZ protein [Source:MGI Symbol;Acc:MGI:1343085] |
| Ensembl ID | ENSMUSG00000057522 |
| Bio databases IDs | |
| Aliases | speckle-type BTB/POZ protein |
| Synonyms | BTBD32, CTB75, NEDMACE, NEDMIDF, NSDVS1, NSDVS2, Pcif1, speckle-type BTB/POZ protein, TEF2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spop often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- MATH
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- BTB/POZ domain
- transcription factor binding
- TRAF domain
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hereditary disorder
- tumorigenesis
- Nabais Sa-de Vries syndrome type 2
- Nabais Sa-de Vries syndrome type 1
- lung adenocarcinoma
- lung adenocarcinoma formation
- organismal death
- lung squamous cell carcinoma
- squamous cell lung cancer
role in cell
- expression in
- differentiation
- phosphorylation in
- proliferation
- degradation in
- migration
- invasion by
- growth
- apoptosis
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- Nucleus
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spop gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- protein polyubiquitination
- regulation of proteolysis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- Cul3-RING ubiquitin ligase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- ubiquitin protein ligase binding