Prdm16 Gene Summary [Mouse]
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; histone H3K9 methyltransferase activity; and transcription coactivator activity. Involved in several processes, including brown fat cell differentiation; positive regulation of cold-induced thermogenesis; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; and positive regulation of brown fat cell differentiation. Located in nucleus. Part of transcription repressor complex. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study left ventricular noncompaction. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1LL. Orthologous to human PRDM16 (PR/SET domain 16). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prdm16 |
| Official Name | PR domain containing 16 [Source:MGI Symbol;Acc:MGI:1917923] |
| Ensembl ID | ENSMUSG00000039410 |
| Bio databases IDs | |
| Aliases | PR domain containing 16 |
| Synonyms | 5730557K01RIK, CMD1LL, csp1, KMT8F, LOC100290519, LOC103692529, LOC647868, LVNC8, MEL1, PFM13, PR domain containing 16, PR/SET domain 16 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prdm16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- SMAD binding
- RD rich domain
- transcription regulator
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
- transcription co-activator
- DNA binding domain
- nucleic acid binding
- transcription factor binding
- protein binding
- sequence-specific DNA binding
- histone lysine N-methyltransferase activity (H3-K9 specific)
- zinc finger
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- histone methyltransferase
- C-terminal-binding protein interaction domain
- double-stranded DNA binding
- Zinc-finger double domain
- SET domain
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
Pathways
Biological processes and signaling networks where the Prdm16 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic pain
- migraines
- headache
- obesity
- heart failure
- hypertension
- ulcerative colitis
- left ventricular noncompaction type 8
- dilated cardiomyopathy type 1LL
- open-angle glaucoma
role in cell
- apoptosis
- signaling in
- expression in
- proliferation
- upregulation in
- function
- activation in
- differentiation
- growth
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- aggresome
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prdm16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- heterochromatin organization
- brown fat cell differentiation
- chromatin remodeling
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- regulation of cellular respiration
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of transforming growth factor beta receptor signaling pathway
- regulation of transcription from RNA polymerase II promoter
- methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcriptional repressor complex
- cytosol
- aggresome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription cofactor activity
- transcription coactivator activity
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- histone methyltransferase activity (H3-K9 specific)
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription