Golga2 Gene Summary [Mouse]
Enables importin-alpha family protein binding activity. Involved in asymmetric cell division and meiotic spindle assembly. Acts upstream of or within Golgi localization and positive regulation of axonogenesis. Located in Golgi apparatus; perinuclear region of cytoplasm; and spindle pole. Is expressed in several structures, including brain; eye; gonad; musculoskeletal system; and unsegmented mesenchyme. Orthologous to human GOLGA2 (golgin A2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Golga2 |
| Official Name | golgi autoantigen, golgin subfamily a, 2 [Source:MGI Symbol;Acc:MGI:2139395] |
| Ensembl ID | ENSMUSG00000002546 |
| Bio databases IDs | |
| Aliases | golgi autoantigen, golgin subfamily a, 2 |
| Synonyms | DEDHMB, GM130, GOLG2A, GOLGIN 95, golgin A2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Golga2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chromosome segregation protein SMC, common bacterial type
- microtubule binding
- RecF/RecN/SMC N terminal domain
- exonuclease SbcC
- binding protein
- protein kinase binding
- GM130 C-terminal binding motif
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- identical protein binding
- Putative golgin subfamily A member 2-like protein 5
- syntaxin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight gain
- tumorigenesis
- developmental delay with hypotonia, myopathy, and brain abnormalities
- globozoospermia
- ataxia
- oligozoospermia
- ataxic gait
- neurological signs
- neuromuscular disease
role in cell
- morphology
- proliferation
- migration
- formation
- growth
- transactivation in
- number
- abnormal morphology
- organization
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- Golgi-enriched fraction
- membrane fraction
- juxtanuclear Golgi region
- perinuclear Golgi regions
- Golgi region
- intracellular space
- perinuclear region
- microvesicles
- cellular membrane
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- cis face of the Golgi apparatus
- Golgi membrane
- Golgi stacks
- trans Golgi network
- cis Golgi networks
- perinuclear space
- spindle pole
- photoreceptor inner segments
- transport vesicles
- cytoplasmic vesicles
- Golgi cisternae
- mitotic spindle
- perikaryon
- cone inner segments
- Golgi vesicles
- cis Golgi cisternae
- detergent-soluble fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Golga2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- centrosome cycle
- Golgi organization
- Golgi disassembly
- microtubule nucleation
- protein transport
- protein glycosylation
- asymmetric cell division
- negative regulation of protein binding
- Golgi ribbon formation
- spindle assembly
- ER to Golgi vesicle-mediated transport
- protein homotetramerization
- negative regulation of autophagy
- positive regulation of protein glycosylation
- spindle assembly involved in meiosis
- spindle assembly involved in mitosis
Cellular Component
Where in the cell the gene product is active
- cis-Golgi network
- mitotic spindle
- Golgi cisterna membrane
- spindle pole
- ER to Golgi transport vesicle
- Golgi apparatus
- Golgi membrane
- Golgi cis cisterna
- endoplasmic reticulum-Golgi intermediate compartment membrane
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- identical protein binding
- protein binding
- syntaxin binding
- cadherin binding
- microtubule binding