TSHZ2 Gene Summary [Human]
This gene is a member of the teashirt C2H2-type zinc-finger protein family of transcription factors. This gene encodes a protein with five C2H2-type zinc fingers, a homeobox DNA-binding domain and a coiled-coil domain. This nuclear protein is predicted to act as a transcriptional repressor. This gene is thought to play a role in the development and progression of breast and other types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
Details
| Type | Protein Coding |
| Official Symbol | TSHZ2 |
| Official Name | teashirt zinc finger homeobox 2 [Source:HGNC Symbol;Acc:HGNC:13010] |
| Ensembl ID | ENSG00000182463 |
| Bio databases IDs | |
| Aliases | teashirt zinc finger homeobox 2 |
| Synonyms | 2900073F20RIK, B830045G17, C20ORF17, LOC100288461, LOC100292165, mKIAA4248, Mtsh2, OVC10-2, Sdccag33l, teashirt2, teashirt zinc finger family member 2, teashirt zinc finger homeobox 2, TSH2, ZABC2, Zfp218, ZNF218 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TSHZ2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- protein binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- head and neck squamous cell carcinoma
- lung squamous cell carcinoma
- squamous cell lung cancer
- Alzheimer disease
- sarcoidosis
- urothelial bladder carcinoma
- transitional cell bladder cancer
- non-insulin-dependent diabetes mellitus
- HER2 negative hormone receptor negative breast cancer
- renal clear cell adenocarcinoma
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TSHZ2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- metal ion binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity