DLGAP5 Gene Summary [Human]
Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including centrosome localization; kinetochore assembly; and mitotic spindle organization. Located in several cellular components, including centrosome; cytosol; and mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | DLGAP5 |
| Official Name | DLG associated protein 5 [Source:HGNC Symbol;Acc:HGNC:16864] |
| Ensembl ID | ENSG00000126787 |
| Bio databases IDs | |
| Aliases | DLG associated protein 5 |
| Synonyms | C77459, C86398, Dap-5, DLG7, DLG associated protein 5, HURP, mKIAA0008 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DLGAP5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding domain
- protein binding
- Cdk1-CyclinB-phosphorylation site
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bladder cancer
- epithelial cancer
- neoplasia
- breast cancer
- non-small cell lung carcinoma
- non-small cell lung cancer
- lymphomagenesis
- B cell cancer
- colorectal cancer
- septic shock
role in cell
- phosphorylation in
- expression in
- accumulation
- accumulation in
- proliferation
- invasion by
- migration
- growth
- polymerization
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- centrosome
- cytosol
- spindle fibers
- mitotic spindle
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DLGAP5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- centrosome localization
- mitotic spindle organization
- signaling
- chromosome segregation
- positive regulation of mitotic metaphase/anaphase transition
- kinetochore assembly
- mitotic chromosome movement towards spindle pole
- regulation of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- spindle pole centrosome
- mitotic spindle
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- microtubule binding