CD72 Gene Summary [Human]
Predicted to enable signaling receptor binding activity. Predicted to be involved in cell adhesion. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CD72 |
| Official Name | CD72 molecule [Source:HGNC Symbol;Acc:HGNC:1696] |
| Ensembl ID | ENSG00000137101 |
| Bio databases IDs | |
| Aliases | CD72 molecule |
| Synonyms | CD72 antigen, CD72b, CD72c, CD72 molecule, LOC100504743, Ly-19, Ly-32, LYB2, Ly-m19 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CD72 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- immunoreceptor tyrosine-based inhibition motif
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins
- Clathrin-binding domain of Huntingtin-interacting protein 1
- Lectin C-type domain
- protein binding
- receptor binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the CD72 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dextran sodium sulfate-induced colitis
- laser induced choroidal neovascularization
- glomerulonephritis
- autoimmune disease
- nonalcoholic fatty liver disease
- psoriatic arthritis
role in cell
- phosphorylation in
- activation
- quantity
- number
- differentiation
- production in
- proliferation
- binding in
- accumulation in
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CD72 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- transmembrane signaling receptor activity
- carbohydrate binding
- receptor binding