GRB2 Gene Summary [Human]
The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GRB2 |
| Official Name | growth factor receptor bound protein 2 [Source:HGNC Symbol;Acc:HGNC:4566] |
| Ensembl ID | ENSG00000177885 |
| Bio databases IDs | |
| Aliases | growth factor receptor bound protein 2 |
| Synonyms | ASH, Ash-psi, EGFRBP-GRB2, GRAB2, GRBS, growth factor receptor bound protein 2, LOC103690155, MST084, MSTP084, NCKAP2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GRB2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- epidermal growth factor receptor binding
- protein phosphatase binding
- protein binding activity, bridging
- guanyl-nucleotide exchange factor adaptor
- phosphoprotein binding
- enzyme binding
- phosphotyrosine binding
- ephrin receptor binding
- protein domain specific binding
- protein binding
- phosphotyrosine binding domain
- Src-homology 2 binding domain
- identical protein binding
- SH3-domain binding
- neurotrophin TRKA receptor binding
- Sh3 domain binding motif
- Src Homology 3 domain superfamily
- binding protein
- Src homology 2 (SH2) domain
- transmembrane receptor protein tyrosine kinase adaptor protein
- FLVRES motif
Pathways
Biological processes and signaling networks where the GRB2 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Angiopoietin Signaling
- CNTF Signaling
- EGF Signaling
- ErbB Signaling
- ErbB4 Signaling
- Glucocorticoid Receptor Signaling
- GM-CSF Signaling
- IL-7 Signaling Pathway
- JAK/Stat Signaling
- Neuregulin Signaling
- Neurotrophin/TRK Signaling
- NGF Signaling
- Oncostatin M Signaling
- PAK Signaling
- Paxillin Signaling
- PPAR Signaling
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Renal Cell Carcinoma Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Th1 Pathway
- Th2 Pathway
- TREM1 Signaling
- VEGF Family Ligand-Receptor Interactions
- VEGF Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- epithelial cancer
- neoplasia
- epithelial neoplasia
- cancer
- cardiac fibrosis
- neonatal late-onset sepsis
- uterine leiomyoma
- leiomyomatosis
- multiple sclerosis
role in cell
- degradation in
- proliferation
- activation in
- binding in
- expression in
- phosphorylation in
- formation
- formation in
- neuroprotection
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- plasma membrane fraction
- high-density microsomal fractions
- intracellular membrane fractions
- nuclear fraction
- Golgi-enriched fraction
- membrane fraction
- presynaptic regions
- cell surface
- perinuclear region
- pericentriolar regions
- cellular tail
- cellular membrane
- cell cortex
- Nucleus
- Plasma Membrane
- endosomes
- vesicles
- centrosome
- microtubules
- intercellular junctions
- cytosol
- vesicle membrane
- membrane ruffles
- nucleoplasm
- nucleoli
- dendritic spines
- growth cone
- sarcolemma
- actin stress fibers
- membrane rafts
- microvilli
- perikaryon
- axons
- dendrites
- postsynaptic density
- clathrin-coated vesicles
- phagosomes
- synaptic vesicle fractions
- synaptosomal fractions
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GRB2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of MAPK cascade
- Schwann cell development
- insulin receptor signaling pathway
- signal transduction
- epidermal growth factor receptor signaling pathway
- branching involved in labyrinthine layer morphogenesis
- signal transduction in response to DNA damage
- insulin-like growth factor receptor signaling pathway
- fibroblast growth factor receptor signaling pathway
- Ras protein signal transduction
- myelination
- natural killer cell mediated cytotoxicity
- positive regulation of actin filament polymerization
- cellular response to ionizing radiation
- endodermal cell differentiation
- actin cytoskeleton organization
- receptor internalization
- positive regulation of reactive oxygen species metabolic process
- B cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- Golgi apparatus
- nucleolus
- plasma membrane
- nucleoplasm
- nucleus
- cell-cell junction
- extracellular vesicular exosome
- endosome
- cytoplasm
- vesicle membrane
- cell cortex
- cytosol
- signalosome
- Grb2-EGFR complex
Molecular Function
What the gene product does at the molecular level
- guanyl-nucleotide exchange factor adaptor activity
- protein kinase binding
- identical protein binding
- protein phosphatase binding
- ephrin receptor binding
- epidermal growth factor receptor binding
- transmembrane receptor protein tyrosine kinase adaptor activity
- neurotrophin TRKA receptor binding
- phosphotyrosine binding
- protein binding
- RNA binding
- insulin receptor substrate binding
- SH3 domain binding