Naa20 Gene Summary [Mouse]
Predicted to enable protein-N-terminal amino-acid acetyltransferase activity. Predicted to be involved in N-terminal protein amino acid acetylation and regulation of actin cytoskeleton organization. Predicted to be located in cytosol and nucleus. Predicted to be part of NatB complex. Is expressed in several structures, including brain; retina; skin; stomach; and submandibular gland primordium. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 73. Orthologous to human NAA20 (N-alpha-acetyltransferase 20, NatB catalytic subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Naa20 |
| Official Name | N(alpha)-acetyltransferase 20, NatB catalytic subunit [Source:MGI Symbol;Acc:MGI:1915127] |
| Ensembl ID | ENSMUSG00000002728 |
| Bio databases IDs | |
| Aliases | N(alpha)-acetyltransferase 20, NatB catalytic subunit |
| Synonyms | 1500004D14RIK, 2900026I01Rik, ARD1, D2Ertd186e, dJ1002M8.1, MRT73, N-alpha-acetyltransferase 20, NatB catalytic subunit, N(alpha)-acetyltransferase 20, NatB catalytic subunit, NAT3, NAT3P, NAT5, NAT5P, N-α-acetyltransferase 20, NatB catalytic subunit, N(α)-acetyltransferase 20, NatB catalytic subunit |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Naa20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Acetyltransferase (GNAT) family
- NAT_SF
- Acetyltransferase (GNAT) domain
- enzyme
- protein binding
- ribosomal-protein-alanine acetyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Naa20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- N-terminal peptidyl-aspartic acid acetylation
- N-terminal peptidyl-glutamine acetylation
- N-terminal peptidyl-methionine acetylation
- N-terminal peptidyl-glutamic acid acetylation
- N-terminal protein amino acid acetylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- NatB complex
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- peptide alpha-N-acetyltransferase activity