Srgn Gene Summary [Mouse]
Predicted to enable collagen binding activity. Involved in negative regulation of cytokine production; protein localization to secretory granule; and protein processing. Located in mast cell granule. Is expressed in several structures, including autopod; central nervous system; liver; lower jaw; and thymus primordium. Orthologous to human SRGN (serglycin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Srgn |
| Official Name | serglycin [Source:MGI Symbol;Acc:MGI:97756] |
| Ensembl ID | ENSMUSG00000020077 |
| Bio databases IDs | |
| Aliases | serglycin |
| Synonyms | haematoPOETIC PROTEOGLYCAN CORE, HEMATOPOETIC PROTEOGLYCAN CORE, PGSG, PPG, PRG, PRG1, Serglycin, Sgc |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Srgn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- collagen binding
- protein binding
- Serglycin
Pathways
Biological processes and signaling networks where the Srgn gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- ulcerative colitis
- adenoma formation
- obesity
- aldosterone producing adrenocortical adenoma
- organismal death
- Alzheimer disease
- non-small cell lung cancer
- squamous cell cancer of the oral cavity
- uterine leiomyoma
role in cell
- expression in
- cell viability
- quantity
- apoptosis
- migration
- invasion by
- proliferation
- adhesion
- morphology
- necrosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- Extracellular Space
- perinuclear region
- Nucleus
- endosomes
- lysosome
- Golgi Apparatus
- granules
- Golgi membrane
- alpha granules
- zymogen granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Srgn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maintenance of granzyme B location in T cell secretory granule
- T cell secretory granule organization
- negative regulation of bone mineralization
- mast cell secretory granule organization
- secretory granule organization
- maintenance of protease location in mast cell secretory granule
- apoptotic process
- protein processing
- negative regulation of cytokine production
- biomineral tissue development
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- extracellular space
- cytolytic granule
- mast cell granule
- secretory granule
- Golgi apparatus
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding