Naa50 Gene Summary [Mouse]
Predicted to enable histone H4 acetyltransferase activity and protein-N-terminal amino-acid acetyltransferase activity. Predicted to be involved in N-terminal protein amino acid acetylation; establishment of mitotic sister chromatid cohesion; and mitotic sister chromatid cohesion, centromeric. Predicted to be located in cytosol and nucleolus. Predicted to be part of NatA complex. Is expressed in several structures, including alimentary system; integumental system; nose; respiratory system; and telencephalon. Orthologous to human NAA50 (N-alpha-acetyltransferase 50, NatE catalytic subunit). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Naa50 |
| Official Name | N(alpha)-acetyltransferase 50, NatE catalytic subunit [Source:MGI Symbol;Acc:MGI:1919367] |
| Ensembl ID | ENSMUSG00000022698 |
| Bio databases IDs | |
| Aliases | N(alpha)-acetyltransferase 50, NatE catalytic subunit |
| Synonyms | 2600005K24Rik, 2810441M03Rik, hNaa50p, LOC100506638, LOC102553099, MAK3, Mak3p, N-alpha-acetyltransferase 50, NatE catalytic subunit, N(alpha)-acetyltransferase 50, NatE catalytic subunit, NAT13, NAT13P, NAT5, NAT5P, N-α-acetyltransferase 50, NatE catalytic subunit, N(α)-acetyltransferase 50, NatE catalytic subunit, SAN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Naa50 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone acetyltransferase
- Acetyltransferase (GNAT) family
- N-acetyltransferase
- peptide alpha-N-acetyltransferase
- NAT_SF
- Acetyltransferase (GNAT) domain
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- non-small cell lung cancer
- prostate cancer
- lung squamous cell carcinoma
- squamous cell lung cancer
- organismal death
- lung adenocarcinoma
- lung adenocarcinoma formation
regulated by
- SNCA
- L-cystine
role in cell
- proliferation
- cohesion
- cohesion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- Nucleus
- cytosol
- nucleoli
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Naa50 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- mitotic sister chromatid cohesion
- establishment of mitotic sister chromatid cohesion
- N-terminal protein amino acid acetylation
- mitotic sister chromatid cohesion, centromeric
Cellular Component
Where in the cell the gene product is active
- nucleus
- NatA complex
- extracellular vesicular exosome
- cytoplasm
- cytosol
- nucleolus
Molecular Function
What the gene product does at the molecular level
- protein binding
- peptidyl-lysine N-acetyltransferase activity
- peptide alpha-N-acetyltransferase activity
- H4 histone acetyltransferase activity