Naa15 Gene Summary [Mouse]
Enables N-acetyltransferase activity. Predicted to be involved in several processes, including N-terminal protein amino acid acetylation; positive regulation of DNA-templated transcription; and protein stabilization. Located in cytoplasm. Is expressed in several structures, including brain; cornea endothelium; genitourinary system; gut; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 50. Orthologous to human NAA15 (N-alpha-acetyltransferase 15, NatA auxiliary subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Naa15 |
| Official Name | N(alpha)-acetyltransferase 15, NatA auxiliary subunit [Source:MGI Symbol;Acc:MGI:1922088] |
| Ensembl ID | ENSMUSG00000063273 |
| Bio databases IDs | |
| Aliases | N(alpha)-acetyltransferase 15, NatA auxiliary subunit |
| Synonyms | 5730450D16Rik, 6330400I15, AK091308, ASTBDN, Ga19, mNAT1, MRD50, N-alpha-acetyltransferase 15, NatA auxiliary subunit, N(alpha)-acetyltransferase 15, NatA auxiliary subunit, NARG1, NAT1P, NATH, NMDA receptor-regulated gene 1, N-α-acetyltransferase 15, NatA auxiliary subunit, N(α)-acetyltransferase 15, NatA auxiliary subunit, Similar to tubedown 1, TBDN, Tbdn-1, TBDN100, TRANSCRIPTIONAL COACTIVATOR TUBEDOWN-100, Tubedown-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Naa15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- N-acetyltransferase
- N-terminal acetyltransferase A, auxiliary subunit
- ribosome binding
- protein binding
- acetyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurodevelopmental disorder
- autosomal dominant mental retardation type 50
- preeclampsia
- autism
- hereditary disorder
- backache
- neuroblastoma
- neuroblastoma formation
- mental retardation
- global developmental delay
role in cell
- expression in
- apoptosis
- invasion by
- cohesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- polysomes
- cytosol
- nuclear bodies
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Naa15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- angiogenesis
- negative regulation of apoptotic process
- N-terminal peptidyl-methionine acetylation
- cell differentiation
- N-terminal protein amino acid acetylation
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- NatA complex
- nuclear body
- cytoplasm
- intracellular membrane-bounded organelle
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- acetyltransferase activity
- ribosome binding