Reg3g Gene Summary [Mouse]
This gene encodes a C-type lectin that demonstrates bactericidal activity. This gene is predominantly expressed in the distal small intestine where the encoded protein undergoes proteolytic processing by trypsin. Mice lacking the encoded protein exhibit altered mucus distribution, increased bacterial contact with the epithelium, and elevated inflammatory markers in the ileum, and low-grade inflammation. [provided by RefSeq, Jun 2016]
Details
| Type | Retained Intron |
| Official Symbol | Reg3g |
| Official Name | regenerating islet-derived 3 gamma [Source:MGI Symbol;Acc:MGI:109406] |
| Ensembl ID | ENSMUSG00000030017 |
| Bio databases IDs | |
| Aliases | regenerating islet-derived 3 gamma |
| Synonyms | PAP3, PAPIII, REG-3-gamma, REG-3-γ, regenerating family member 3 gamma, regenerating family member 3 γ, Regenerating islet derived 3 gamma, Regenerating islet derived 3 γ, REG III gamma, REG III γ |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Reg3g often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- Lectin C-type domain
- peptidoglycan binding
- hormone
- carbohydrate binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dextran sodium sulfate-induced colitis
- infection by Citrobacter rodentium
role in cell
- proliferation
- number
- differentiation
- recruitment
- killing
- clearance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granules