Tyro3 Gene Summary [Mouse]
Predicted to enable phosphatidylinositol 3-kinase binding activity; transmembrane receptor protein tyrosine kinase activity; and virus receptor activity. Involved in several processes, including platelet aggregation; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and regulation of defense response. Acts upstream of or within several processes, including nervous system development; substrate adhesion-dependent cell spreading; and vagina development. Predicted to be located in cell surface; endoplasmic reticulum membrane; and nuclear envelope. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; limb; and sensory organ. Used to study autoimmune disease. Orthologous to human TYRO3 (TYRO3 protein tyrosine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tyro3 |
| Official Name | TYRO3 protein tyrosine kinase 3 [Source:MGI Symbol;Acc:MGI:104294] |
| Ensembl ID | ENSMUSG00000027298 |
| Bio databases IDs | |
| Aliases | TYRO3 protein tyrosine kinase 3 |
| Synonyms | Brt, BYK, Dtk, Etk-2, etk2/tyro3, Rek, RSE, Sky, Tif, tk19-1, TK19-2, Tyro2, TYRO3 protein tyrosine kinase, TYRO3 protein tyrosine kinase 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tyro3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- viral receptor
- Fibronectin type 3 domain
- protein-tyrosine kinase
- Protein kinase domain
- cytoplasmic domain
- Immunoglobulin like
- intracellular domain
- immunoglobulin-like protein domain
- Tyrosine kinase, catalytic domain
- Immunoglobulin V-set domain
- extracellular domain
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- immunoglobulin domain
- ectodomain
- Immunoglobulin I-set domain
- Purple acid Phosphatase, N-terminal domain
- protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- phosphoinositide 3-kinase binding
- Protein Kinases, catalytic domain
- FN3
- transmembrane domain
- tyrosine kinase domain
Pathways
Biological processes and signaling networks where the Tyro3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- advanced non-small cell lung cancer
- breast cancer
- neoplasia
- metastatic non-small cell lung cancer
- autoimmune disease
- progressive non-small cell lung cancer
- differentiated thyroid cancer
- tall cell variant of papillary thyroid carcinoma
- advanced hepatocellular carcinoma
- well-differentiated neuroendocrine tumor
role in cell
- activation in
- proliferation
- expression in
- differentiation
- phosphorylation in
- apoptosis
- cell death
- cellular infiltration by
- survival
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- cell surface
- cellular membrane
- Nucleus
- endoplasmic reticulum membrane
- nuclear envelope
- synaptic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tyro3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- vagina development
- multicellular organismal development
- nervous system development
- protein autophosphorylation
- negative regulation of lymphocyte activation
- cell adhesion
- negative regulation of innate immune response
- ovulation cycle
- negative regulation of neuron apoptotic process
- protein kinase B signaling cascade
- neuron migration
- substrate adhesion-dependent cell spreading
- positive regulation of kinase activity
- establishment of localization in cell
- platelet aggregation
- cell migration
- platelet activation
- secretion by cell
- neuron apoptotic process
- negative regulation of toll-like receptor signaling pathway
- signal transduction
- negative regulation of inflammatory response
- spermatogenesis
- apoptotic cell clearance
- forebrain cell migration
- transmembrane receptor protein tyrosine kinase signaling pathway
- neuropeptide signaling pathway
- neuron homeostasis
- natural killer cell differentiation
- phagocytosis
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- endoplasmic reticulum membrane
- nucleus
- receptor complex
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- ATP binding
- phosphatidylinositol 3-kinase binding
- protein tyrosine kinase activity
- protein binding
- transmembrane receptor protein tyrosine kinase activity
- viral receptor activity