Tslp Gene Summary [Mouse]
Enables cytokine activity. Predicted to be involved in several processes, including defense response to other organism; positive regulation of cytokine production; and positive regulation of signal transduction. Is active in extracellular space. Is expressed in ileum; male reproductive gland or organ; and skin. Used to study atopic dermatitis; autoimmune hemolytic anemia; cryoglobulinemia; and membranoproliferative glomerulonephritis. Orthologous to human TSLP (thymic stromal lymphopoietin). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tslp |
| Official Name | thymic stromal lymphopoietin [Source:MGI Symbol;Acc:MGI:1855696] |
| Ensembl ID | ENSMUSG00000024379 |
| Bio databases IDs | |
| Aliases | thymic stromal lymphopoietin |
| Synonyms | LOC682183, thymic stromal lymphopoietin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tslp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- interleukin-7 receptor binding
- protein binding
- cytokine
- Thymic stromal lymphopoietin
Pathways
Biological processes and signaling networks where the Tslp gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- breast cancer
- proteinuria
- experimental eosinophilic esophagitis
- asthma
- severe asthma
- chronic rhinosinusitis with nasal polyps
- organismal death
- pruritus
- spontaneous abortion
role in cell
- expression in
- migration
- number
- survival
- differentiation
- growth
- transcription in
- apoptosis
- proliferation
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tslp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of inflammatory response
- interleukin-7-mediated signaling pathway
- positive regulation of cell proliferation
- positive regulation of tyrosine phosphorylation of STAT protein
- JAK-STAT cascade
- positive regulation of cytokine-mediated signaling pathway
- positive regulation of interleukin-13 production
- negative regulation of apoptotic process
- positive regulation of mast cell activation
- positive regulation of chemokine (C-C motif) ligand 1 production
- positive regulation of interleukin-6 production
- positive regulation of chemokine production
- positive regulation of interleukin-10 production
- positive regulation of granulocyte colony-stimulating factor production
- positive regulation of interleukin-5 production
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- interleukin-7 receptor binding
- cytokine activity