Sod1 Gene Summary [Mouse]
Enables superoxide dismutase activity. Involved in axonal transport; negative regulation of inflammatory response; and positive regulation of phagocytosis. Acts upstream of or within several processes, including action potential initiation; determination of adult lifespan; and neurogenesis. Located in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study amyotrophic lateral sclerosis type 1; dry eye syndrome; and low tension glaucoma. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; artery disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and neurodegenerative disease (multiple). Orthologous to human SOD1 (superoxide dismutase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sod1 |
| Official Name | superoxide dismutase 1, soluble [Source:MGI Symbol;Acc:MGI:98351] |
| Ensembl ID | ENSMUSG00000022982 |
| Bio databases IDs | |
| Aliases | superoxide dismutase 1, soluble |
| Synonyms | ALS, ALS1, B430204E11Rik, Cu/Zn-SOD, CuZn-SOD, czSOD, HEL-S-44, hSod1, Ipo-1, IPOA, SOD, SOD1L1, SODC, STAHP, superoxide dismutase 1, superoxide dismutase 1, soluble |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sod1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme binding
- enzyme
- protein binding
- identical protein binding
- superoxide dismutase
- metal binding domain
- DERL1 binding domain
- copper ion binding
- zinc ion binding
- protein phosphatase 2B binding
- copper binding domain
- protein homodimerization
- chaperone binding
- Copper/zinc superoxide dismutase (SODC)
- Cu-Zn_Superoxide_Dismutase
Pathways
Biological processes and signaling networks where the Sod1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- muscle weakness
- epithelial cancer
- epithelial neoplasia
- cancer
- neoplasia
- paralysis
- diabetes mellitus
- pathological denervation
- breast cancer
phenotypes
- Meibomian gland inflammation
- abnormal Meibomian gland acinus morphology
- abnormal Meibomian gland morphology
- abnormal Meibomian gland physiology
- abnormal auditory brainstem response waveform shape
- abnormal body fat mass
- abnormal cardiovascular system physiology
- abnormal cochlear nerve morphology
- abnormal common lymphocyte progenitor cell morphology
- abnormal corneal epithelium morphology
- abnormal corticospinal tract morphology
- abnormal enzyme/coenzyme level
- abnormal eye electrophysiology
- abnormal gait
- abnormal liver morphology
- abnormal locomotor activation
- abnormal mitochondrial physiology
- abnormal mitochondrion morphology
- abnormal motor neuron innervation pattern
- abnormal muscle fiber morphology
- abnormal neuron physiology
- abnormal ovary morphology
- abnormal retinal ganglion layer morphology
- abnormal retinal nerve fiber layer morphology
- abnormal tear production
- astrocytosis
- blepharitis
- cochlear ganglion degeneration
- cochlear hair cell degeneration
- cochlear inner hair cell degeneration
- cochlear outer hair cell degeneration
- deafness
- decreased a wave amplitude
- decreased b wave amplitude
- decreased body weight
- decreased cardiac muscle contractility
- decreased circulating luteinizing hormone level
- decreased common myeloid progenitor cell number
- decreased corpora lutea number
- decreased erythrocyte cell number
- decreased fibroblast proliferation
- decreased grip strength
- decreased hemoglobin content
- decreased litter size
- decreased mature ovarian follicle number
- decreased motor neuron number
- decreased retinal ganglion cell number
- decreased tear production
- dilated mitochondria
- disorganized mitochondrial cristae
- disorganized retinal inner nuclear layer
- disorganized retinal outer nuclear layer
- enhanced behavioral response to xenobiotic
- female infertility
- hepatic steatosis
- hypoactivity
- hyporesponsive to tactile stimuli
- impaired coordination
- impaired ovarian folliculogenesis
- increased circulating interleukin-6 level
- increased circulating tumor necrosis factor level
- increased fibroblast apoptosis
- increased hepatocellular carcinoma incidence
- increased interleukin-6 secretion
- increased liver tumor incidence
- increased myocardial infarction size
- increased or absent threshold for auditory brainstem response
- increased sensitivity to xenobiotic induced morbidity/mortality
- increased susceptibility to age-related hearing loss
- increased susceptibility to noise-induced hearing loss
- increased thermal nociceptive threshold
- increased tumor necrosis factor secretion
- kyphosis
- lethality incomplete penetrance
- liver inflammation
- microgliosis
- motor neuron degeneration
- myocardium necrosis
- organ of Corti degeneration
- oxidative stress
- pillar cell degeneration
- positive geotaxis
- premature death
- progressive muscle weakness
- reduced female fertility
- small ovary
- suppressed circulating follicle stimulating hormone level
- thin retinal inner nuclear layer
- thin retinal outer nuclear layer
- thin stria vascularis
- tremors
role in cell
- expression in
- growth
- cell viability
- phosphorylation in
- number
- production in
- activation
- activation in
- loss
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- myelin enriched fraction
- mitochondrial fraction
- extracellular vesicles
- Extracellular Space
- Nucleus
- Plasma Membrane
- centrosome
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- cytoplasmic aggregates
- cytosol
- microsome
- mitochondrial intermembrane space
- nucleoplasm
- photoreceptor outer segments
- cytoplasmic vesicles
- rough endoplasmatic reticulum
- peroxisomes
- secretory granules
- perikaryon
- dendrites
- plasma
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sod1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- auditory receptor cell stereocilium organization
- heart contraction
- determination of adult lifespan
- relaxation of vascular smooth muscle
- negative regulation of developmental process
- response to axon injury
- sensory perception of sound
- cellular iron ion homeostasis
- regulation of mitochondrial membrane potential
- apoptotic process
- peripheral nervous system myelin maintenance
- germ cell programmed cell death
- regulation of protein kinase activity
- negative regulation of inflammatory response
- regulation of organ growth
- response to hydrogen peroxide
- response to superoxide
- superoxide metabolic process
- negative regulation of cholesterol biosynthetic process
- positive regulation of catalytic activity
- removal of superoxide radicals
- regulation of GTPase activity
- gene expression
- negative regulation of reproductive process
- positive regulation of phagocytosis
- muscle cell homeostasis
- regulation of multicellular organism growth
- anterograde axon cargo transport
- myeloid cell homeostasis
- response to xenobiotic stimulus
- regulation of T cell differentiation in thymus
- superoxide anion generation
- placenta development
- thymus development
- negative regulation of neuron apoptotic process
- response to ethanol
- response to heat
- locomotory behavior
- transmission of nerve impulse
- regulation of action potential in neuron
- neurofilament cytoskeleton organization
- spermatogenesis
- positive regulation of MAPK cascade
- regulation of blood pressure
- embryo implantation
- ovarian follicle development
- reactive oxygen species metabolic process
- retina homeostasis
- glutathione metabolic process
- positive regulation of apoptotic process
- positive regulation of cytokine production
- retrograde axon cargo transport
- hydrogen peroxide biosynthetic process
- positive regulation of superoxide anion generation
Cellular Component
Where in the cell the gene product is active
- neuronal cell body
- extracellular region
- plasma membrane
- nucleoplasm
- peroxisome
- nucleus
- mitochondrial intermembrane space
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- mitochondrial matrix
- mitochondrion
- dendrite cytoplasm
- cytosol
- cytoplasmic vesicle
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- zinc ion binding
- protein binding
- copper ion binding
- chaperone binding
- small GTPase binding
- superoxide dismutase activity
- protein phosphatase 2B binding