Csf2 Gene Summary [Mouse]
Enables cytokine activity. Acts upstream of or within several processes, including embryonic placenta development; myeloid leukocyte differentiation; and positive regulation of cell population proliferation. Located in extracellular space. Is expressed in several structures, including genitourinary system; hemolymphoid system; liver; lung; and trophectoderm. Used to study pulmonary alveolar proteinosis. Human ortholog(s) of this gene implicated in acute myeloid leukemia; juvenile myelomonocytic leukemia; neutropenia; pulmonary alveolar proteinosis; and visceral leishmaniasis. Orthologous to human CSF2 (colony stimulating factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Csf2 |
| Official Name | colony stimulating factor 2 (granulocyte-macrophage) [Source:MGI Symbol;Acc:MGI:1339752] |
| Ensembl ID | ENSMUSG00000018916 |
| Bio databases IDs | |
| Aliases | colony stimulating factor 2 (granulocyte-macrophage) |
| Synonyms | colony stimulating factor 2, colony stimulating factor 2 (granulocyte-macrophage), CSF, Csfgm, GMCSF, MGI-IGM, NIF |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Csf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- CSF2
- alpha helix
- protein binding
- granulocyte macrophage colony-stimulating factor receptor binding
- cytokine
- growth factor
Pathways
Biological processes and signaling networks where the Csf2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Airway Inflammation in Asthma
- Antioxidant Action of Vitamin C
- Communication between Innate and Adaptive Immune Cells
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Dendritic Cell Maturation
- Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F
- Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F
- Erythropoietin Signaling
- Fc Epsilon RI Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Glucocorticoid Receptor Signaling
- GM-CSF Signaling
- Hematopoiesis from Multipotent Stem Cells
- Hematopoiesis from Pluripotent Stem Cells
- Hepatic Cholestasis
- Role of Cytokines in Mediating Communication between Immune Cells
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Role of Tissue Factor in Cancer
- Th17 Activation Pathway
- TREM1 Signaling
- VDR/RXR Activation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast or ovarian cancer
- epithelial cancer
- urogenital cancer
- epithelial neoplasia
- cancer
- tumorigenesis
- adenoma formation
- benign neoplasia
- abdominal cancer
- hyperplasia
role in cell
- induction in
- binding
- apoptosis
- formation
- cytotoxicity
- production in
- expression in
- activation in
- cell death
- transmembrane potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- intracellular membrane-bounded organelle
- Cytoplasm
- cell surface
- intracellular space
- perinuclear region
- membrane surface
- Nucleus
- extracellular matrix
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Csf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- granulocyte-macrophage colony-stimulating factor signaling pathway
- positive regulation of cell proliferation
- positive regulation of tyrosine phosphorylation of STAT protein
- embryonic placenta development
- JAK-STAT cascade
- immune response
- positive regulation of interleukin-23 production
- negative regulation of transcription, DNA-dependent
- histamine secretion
- myeloid dendritic cell differentiation
- dendritic cell differentiation
- positive regulation of leukocyte proliferation
- monocyte differentiation
- response to fluid shear stress
- neutrophil differentiation
- macrophage differentiation
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- response to silicon dioxide
- epithelial fluid transport
- cellular response to granulocyte macrophage colony-stimulating factor stimulus
- cellular response to lipopolysaccharide
- positive regulation of gene expression
- regulation of circadian sleep/wake cycle, sleep
- myeloid cell differentiation
- positive regulation of macrophage derived foam cell differentiation
- positive regulation of podosome assembly
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- granulocyte macrophage colony-stimulating factor receptor complex
- intracellular membrane-bounded organelle
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- granulocyte macrophage colony-stimulating factor receptor binding
- growth factor activity
- protein binding
- cytokine activity