Siglece Gene Summary [Mouse]
Enables monosaccharide binding activity and sialic acid binding activity. Acts upstream of or within cell adhesion; negative regulation of inflammatory response; and negative regulation of phagocytosis, engulfment. Located in external side of plasma membrane. Is expressed in several structures, including gonad; heart; hemolymphoid system gland; liver; and lung. Orthologous to several human genes including SIGLEC12 (sialic acid binding Ig like lectin 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Siglece |
| Official Name | sialic acid binding Ig-like lectin E [Source:MGI Symbol;Acc:MGI:1932475] |
| Ensembl ID | ENSMUSG00000030474 |
| Bio databases IDs | |
| Aliases | sialic acid binding Ig-like lectin E |
| Synonyms | Cd170, mSiglec-E, sialic acid binding Ig-like lectin E, Siglec12, Siglec5, Siglec8, Siglec9, Siglecl1 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Siglece often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- monosaccharide binding
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- proximal tail domain
- distal tail domain
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- plasma membrane extracellular face
- membrane rafts