Ptpn11 Gene Summary [Mouse]
Enables cell adhesion molecule binding activity; non-membrane spanning protein tyrosine phosphatase activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of chondrocyte differentiation; positive regulation of cytokine production; and positive regulation of lipopolysaccharide-mediated signaling pathway. Acts upstream of or within several processes, including cell surface receptor signaling pathway; myeloid cell differentiation; and regulation of hormone secretion. Is active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and retina. Used to study several diseases, including Noonan syndrome 1; hepatocellular adenoma; idiopathic scoliosis; intrinsic cardiomyopathy (multiple); and juvenile myelomonocytic leukemia. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 1; atrophic gastritis; juvenile myelomonocytic leukemia; and metachondromatosis. Orthologous to human PTPN11 (protein tyrosine phosphatase non-receptor type 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptpn11 |
| Official Name | protein tyrosine phosphatase, non-receptor type 11 [Source:MGI Symbol;Acc:MGI:99511] |
| Ensembl ID | ENSMUSG00000043733 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase, non-receptor type 11 |
| Synonyms | 2700084A17Rik, BPTP3, CFC, JMML, METCDS, MGC14433, Noonan syndrome 1, NS1, protein tyrosine phosphatase non-receptor type 11, protein tyrosine phosphatase, non-receptor type 11, PTN11, PTP-1D, PTP2C, SAP-2, SHP-2, SH-PTP2, SH-PTP3, Src homology protein 2, SYP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptpn11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- insulin receptor binding
- protein-tyrosine-phoshatase
- cell adhesion molecule binding
- G-protein-coupled receptor binding
- Protein tyrosine phosphatase, catalytic domain
- PTP_DSP_cys
- enzyme
- Protein tyrosine phosphatase, catalytic domain motif
- phosphotyrosine phosphatase domain
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- Protein-tyrosine phosphatase
- receptor signaling complex scaffold protein
- receptor tyrosine kinase binding
- protein phosphatase
- phosphatase
- Src homology 2 (SH2) domain
- cadherin binding
- SHP-2 binding domain
- non-membrane spanning protein tyrosine phosphatase
- protein kinase binding
- catalytic domain
- enzyme binding
- phosphotyrosine binding
- protein domain specific binding
- protein binding
- receptor binding
- phosphatase domain
- PTPase domain
- phosphorylation site
- protein tyrosine phosphatase homology domain
- active site
- tyrosine phosphorylation site
Pathways
Biological processes and signaling networks where the Ptpn11 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Angiopoietin Signaling
- Antiproliferative Role of Somatostatin Receptor 2
- CNTF Signaling
- Ephrin A Signaling
- Fc Epsilon RI Signaling
- GM-CSF Signaling
- IGF-1 Signaling
- IL-2 Signaling
- IL-6 Signaling
- JAK/Stat Signaling
- Leptin Signaling in Obesity
- Melanocyte Development and Pigmentation Signaling
- Mouse Embryonic Stem Cell Pluripotency
- Neuregulin Signaling
- Neurotrophin/TRK Signaling
- Renal Cell Carcinoma Signaling
- Role of JAK family kinases in IL-6-type Cytokine Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Role of JAK2 in Hormone-like Cytokine Signaling
- Thrombopoietin Signaling
- VEGF Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- metastasis
- neoplasia
- tumorigenesis
- lung squamous cell carcinoma
- anemia
- myelodysplastic syndrome
- plasma cell myeloma
- obesity
- glioblastoma cancer
role in cell
- expression in
- production in
- transformation
- phosphorylation in
- cell death
- migration
- apoptosis
- branching
- proliferation
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- raft fractions
- soluble fraction
- membrane fraction
- cell junction
- cell center
- cytoskeleton
- cellular membrane
- focal adhesions
- membrane skeleton
- Nucleus
- centrosome
- Mitochondria
- midbody
- cell-cell contacts
- cytosol
- nucleoplasm
- neuromuscular junctions
- actin stress fibers
- membrane rafts
- central spindle
- kinetochores
- cytoskeletal fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptpn11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inner ear development
- epidermal growth factor receptor signaling pathway
- triglyceride metabolic process
- fibroblast growth factor receptor signaling pathway
- negative regulation of growth hormone secretion
- face morphogenesis
- hormone-mediated signaling pathway
- microvillus organization
- axonogenesis
- positive regulation of interferon-beta production
- platelet formation
- positive regulation of tumor necrosis factor production
- negative regulation of type I interferon production
- positive regulation of insulin receptor signaling pathway
- multicellular organismal reproductive process
- genitalia development
- platelet-derived growth factor receptor signaling pathway
- brain development
- regulation of protein export from nucleus
- positive regulation of mitotic cell cycle
- positive regulation of ossification
- nerve growth factor receptor signaling pathway
- DNA damage checkpoint
- ephrin receptor signaling pathway
- glucose homeostasis
- cellular response to epidermal growth factor stimulus
- positive regulation of interleukin-6 production
- multicellular organism growth
- organ growth
- Bergmann glial cell differentiation
- negative regulation of insulin secretion
- cerebellar cortex formation
- heart development
- integrin-mediated signaling pathway
- negative regulation of cortisol secretion
- cytokine-mediated signaling pathway
- megakaryocyte development
- peptidyl-tyrosine dephosphorylation
- positive regulation of peptidyl-tyrosine phosphorylation
- ERBB signaling pathway
- T cell costimulation
- protein dephosphorylation
- regulation of type I interferon-mediated signaling pathway
- positive regulation of hormone secretion
- positive regulation of glucose import
- regulation of protein complex assembly
- hormone metabolic process
- negative regulation of cell adhesion mediated by integrin
- regulation of cell adhesion mediated by integrin
- homeostasis of number of cells within a tissue
- positive regulation of ERK1 and ERK2 cascade
- negative regulation of chondrocyte differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- cell adhesion molecule binding
- insulin receptor binding
- phosphotyrosine binding
- phosphoprotein phosphatase activity
- protein binding
- non-membrane spanning protein tyrosine phosphatase activity
- protein tyrosine phosphatase activity
- cadherin binding
- peptide hormone receptor binding
- receptor tyrosine kinase binding
- receptor signaling complex scaffold activity
- binding, bridging