Gal3st1 Gene Summary [Mouse]
Enables galactosylceramide sulfotransferase activity. Involved in galactosylceramide metabolic process. Acts upstream of or within galactosylceramide biosynthetic process; myelination; and spermatogenesis. Predicted to be located in membrane. Is expressed in brain; future spinal cord; heart ventricle; and spinal cord cervical region. Orthologous to human GAL3ST1 (galactose-3-O-sulfotransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gal3st1 |
| Official Name | galactose-3-O-sulfotransferase 1 [Source:MGI Symbol;Acc:MGI:1858277] |
| Ensembl ID | ENSMUSG00000049721 |
| Bio databases IDs | |
| Aliases | galactose-3-O-sulfotransferase 1 |
| Synonyms | Cerebroside Sulfotransferase, Cerebroside sulphotransferase, CST, galactose-3-O-sulfotransferase 1, galactose-3-O-sulphotransferase 1, Galactosylceramide Sulfotransferase, Galactosylceramide sulphotransferase, GalCer sulphotransferase, GCST |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gal3st1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sulfotransferase
- enzyme
- Galactose-3-O-sulfotransferase
- galactosylceramide sulfotransferase
- Sulfotransferase family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurological disorder
- azoospermia
- chronic hyperchloremic metabolic acidosis
- demyelination
- ataxia
- hypomyelination
- tremor
- ammonuria
- abnormal involuntary movement
role in cell
- apoptosis
- cellular infiltration by
- morphology
- binding
- abnormal morphology
- formation
- thickness
- myelination
- length
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gal3st1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycerolipid metabolic process
- galactosylceramide metabolic process
- spermatogenesis
- protein N-linked glycosylation
- galactosylceramide biosynthetic process
- myelination
- glycosphingolipid biosynthetic process
- sphingolipid metabolic process
Cellular Component
Where in the cell the gene product is active
- membrane
- Golgi membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- galactosylceramide sulfotransferase activity
- sulfotransferase activity