Tlr1

Predicted to enable several functions, including Toll-like receptor 2 binding activity; identical protein binding activity; and lipopeptide binding activity. Involved in positive regulation of interleukin-6 production and positive regulation of tumor necrosis factor production. Acts upstream of or within defense response. Predicted to be located in Golgi apparatus and membrane raft. Predicted to be part of Toll-like receptor 1-Toll-like receptor 2 protein complex. Predicted to be active in plasma membrane. Is expressed in brain; cerebral cortex; and telencephalon. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; aspergillosis; leprosy; pyelonephritis; and tuberculosis. Orthologous to human TLR1 (toll like receptor 1). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tlr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Tlr1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Tlr1 gene, providing context for its role in the cell.