Ptpn6 Gene Summary [Mouse]
Enables several functions, including phosphotyrosine residue binding activity; protein domain specific binding activity; and protein tyrosine phosphatase activity. Involved in several processes, including epididymis development; negative regulation of cytokine production; and negative regulation of inflammatory response to wounding. Acts upstream of or within several processes, including hemopoiesis; negative regulation of protein phosphorylation; and regulation of lymphocyte activation. Located in cell-cell junction. Part of alpha-beta T cell receptor complex. Is active in cytoplasm. Is expressed in several structures, including central nervous system; liver; retina; and thymus primordium. Orthologous to human PTPN6 (protein tyrosine phosphatase non-receptor type 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptpn6 |
| Official Name | protein tyrosine phosphatase, non-receptor type 6 [Source:MGI Symbol;Acc:MGI:96055] |
| Ensembl ID | ENSMUSG00000004266 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase, non-receptor type 6 |
| Synonyms | 70Z-SHP, HCP, HCPH, HPTP1C, me, protein tyrosine phosphatase non-receptor type 6, protein tyrosine phosphatase, non-receptor type 6, PTP1, PTP-1C, Ptph6, PTPTY-42, SHP-1, SHP-1L, SH-PTP1, Sr Homology Protein 1 Phosphatase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptpn6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- protein-tyrosine-phoshatase
- catalytic domain
- SH2-domain binding
- cell adhesion molecule binding
- Protein tyrosine phosphatase, catalytic domain
- phosphotyrosine binding
- PTP_DSP_cys
- protein binding
- phosphatase domain
- proline rich domain
- Protein tyrosine phosphatase, catalytic domain motif
- SH3-domain binding
- PTPase domain
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- Dual specificity phosphatase, catalytic domain
- hematopoietin/interferon-class (D200-domain) cytokine receptor ligand
- Protein-tyrosine phosphatase
- natural killer cell lectin-like receptor binding
- transmembrane receptor protein tyrosine phosphatase
- phosphatase
- active site
- Src homology 2 (SH2) domain
Pathways
Biological processes and signaling networks where the Ptpn6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Antiproliferative Role of Somatostatin Receptor 2
- B Cell Receptor Signaling
- CD28 Signaling in T Helper Cells
- Chronic Myeloid Leukemia Signaling
- Erythropoietin Signaling
- FGF Signaling
- Growth Hormone Signaling
- IL-3 Signaling
- IL-4 Signaling
- JAK/Stat Signaling
- Melanocyte Development and Pigmentation Signaling
- Natural Killer Cell Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Renin-Angiotensin Signaling
- Role of JAK1, JAK2 and TYK2 in Interferon Signaling
- Role of JAK2 in Hormone-like Cytokine Signaling
- STAT3 Pathway
- Systemic Lupus Erythematosus Signaling
- T Cell Receptor Signaling
- VEGF Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- neoplasia
- familial hemophagocytic lymphohistiocytosis type 2
- natural killer/T-cell lymphoma
- T-cell non-Hodgkin disease
- natural killer cell neoplasia
- chronic inflammatory disorder
- glomerulonephritis
- allergic airway inflammation
- mature T-cell neoplasia
role in cell
- outgrowth
- growth
- activation in
- degranulation
- expression in
- apoptosis
- maturation
- phosphorylation in
- survival
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- soluble fraction
- membrane fraction
- secretory granule lumen
- cell surface
- Extracellular Space
- perinuclear region
- organelle lumens
- cellular membrane
- Nucleus
- Plasma Membrane
- intercellular junctions
- cell-cell contacts
- cytosol
- nucleoplasm
- nucleoli
- membrane rafts
- chromatin
- perikaryon
- dendrites
- apical processes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptpn6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-tyrosine phosphorylation
- negative regulation of angiogenesis
- negative regulation of MAPK cascade
- negative regulation of cell proliferation
- positive regulation of cell proliferation
- hemopoietic progenitor cell differentiation
- mitotic cell cycle
- MAPK cascade
- cytokine-mediated signaling pathway
- platelet formation
- megakaryocyte development
- positive regulation of cell adhesion mediated by integrin
- peptidyl-tyrosine dephosphorylation
- platelet aggregation
- negative regulation of tumor necrosis factor production
- T cell receptor signaling pathway
- intracellular signal transduction
- B cell receptor signaling pathway
- negative regulation of peptidyl-tyrosine phosphorylation
- T cell costimulation
- G-protein coupled receptor signaling pathway
- protein dephosphorylation
- regulation of B cell differentiation
- regulation of type I interferon-mediated signaling pathway
- regulation of apoptotic process
- natural killer cell mediated cytotoxicity
- regulation of release of sequestered calcium ion into cytosol
- negative regulation of interleukin-6 production
- regulation of ERK1 and ERK2 cascade
- negative regulation of T cell receptor signaling pathway
- negative regulation of T cell proliferation
- negative regulation of humoral immune response mediated by circulating immunoglobulin
- T cell proliferation
- cell differentiation
- regulation of G1/S transition of mitotic cell cycle
- negative regulation of mast cell activation involved in immune response
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- specific granule lumen
- extracellular region
- nucleolus
- alpha-beta T cell receptor complex
- plasma membrane
- nucleoplasm
- nucleus
- cell-cell junction
- extracellular vesicular exosome
- cytoplasm
- membrane
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- phosphotyrosine binding
- protein kinase binding
- protein binding
- non-membrane spanning protein tyrosine phosphatase activity
- protein tyrosine phosphatase activity
- cell adhesion molecule binding
- transmembrane receptor protein tyrosine phosphatase activity
- SH3 domain binding
- SH2 domain binding