Cd1d1 Gene Summary [Mouse]
Enables T cell receptor binding activity and endogenous lipid antigen binding activity. Involved in NK T cell differentiation and regulation of immature T cell proliferation in thymus. Acts upstream of or within several processes, including antigen processing and presentation, exogenous lipid antigen via MHC class Ib; positive regulation of cytokine production; and positive regulation of leukocyte activation. Located in endosome; external side of plasma membrane; and lysosome. Is expressed in forebrain; intestine; jaw bone; and liver. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human CD1D (CD1d molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Cd1d1 |
| Official Name | CD1d1 antigen [Source:MGI Symbol;Acc:MGI:107674] |
| Ensembl ID | ENSMUSG00000028076 |
| Bio databases IDs | |
| Aliases | CD1d1 antigen |
| Synonyms | AI747460, Cd1, CD1.1, CD1A, Cd1d1, CD1d1 antigen, CD1d molecule, Ly-38, R3, R3G1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cd1d1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- endosome sorting motif
- lipid antigen binding
- MHC-I family domain
- Immunoglobulin C1-set domain
- histone binding
- YXX-Phi motif
- immunoglobulin domain
- cell adhesion molecule binding
- T-cell receptor binding
- endogenous lipid antigen binding
- protein binding
- exogenous lipid antigen binding
- beta-2-microglobulin binding
- internalization targeting signal
- cytoplasmic domain
- N-linked glycosylation site
- transmembrane domain
- cytosolic tail domain
Pathways
Biological processes and signaling networks where the Cd1d1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- diabetes mellitus
- insulin-dependent diabetes mellitus
- atherosclerosis
- Alzheimer disease
- diabetic nephropathy
- tubulo-interstitial fibrosis
- airway hyperresponsiveness
- arthritis
- lupus nephritis
role in cell
- proliferation
- number
- expression in
- cell viability
- apoptosis
- production in
- cytotoxicity
- response
- differentiation
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- late multivesicular endosome
- Cytoplasm
- cell surface
- intracellular space
- cellular membrane
- endosomes
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- MHC class II compartments
- vesicle membrane
- plasma membrane extracellular face
- recycling endosomes
- early endosomes
- late endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cd1d1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- positive regulation of innate immune response
- innate immune response
- detection of bacterium
- antigen processing and presentation, exogenous lipid antigen via MHC class Ib
- T cell selection
- heterotypic cell-cell adhesion
- positive regulation of T cell proliferation
- antigen processing and presentation, endogenous lipid antigen via MHC class Ib
- positive regulation of T cell mediated cytotoxicity
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- extracellular space
- cytoplasm
- external side of plasma membrane
- endosome membrane
- endoplasmic reticulum
- basolateral plasma membrane
- lysosomal membrane
- plasma membrane
- lysosome
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone binding
- cell adhesion molecule binding
- lipid antigen binding
- beta-2-microglobulin binding
- exogenous lipid antigen binding
- endogenous lipid antigen binding
- lipopeptide binding