Psma8 Gene Summary [Mouse]
Involved in meiotic cell cycle; proteasomal protein catabolic process; and regulation of meiosis I. Located in nucleus. Part of spermatoproteasome complex. Orthologous to human PSMA8 (proteasome 20S subunit alpha 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Psma8 |
| Official Name | proteasome subunit alpha 8 [Source:MGI Symbol;Acc:MGI:1920927] |
| Ensembl ID | ENSMUSG00000036743 |
| Bio databases IDs | |
| Aliases | proteasome subunit alpha 8 |
| Synonyms | 2410072D24Rik, LOC100363246, LOC680840, proteasome 20S subunit alpha 8, proteasome 20S subunit α 8, proteasome subunit alpha 8, proteasome subunit α 8, PSMA7L, RGD1311659 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Psma8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ntn_hydrolase
- Proteasome subunit A N-terminal signature
- peptidase
- Proteasome subunit A N-terminal signature Add an annotation
- proteasome endopeptidase complex, archaeal, alpha subunit
- protein binding
- Proteasome subunit
Pathways
Biological processes and signaling networks where the Psma8 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Psma8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- meiotic cell cycle
- proteasomal ubiquitin-dependent protein catabolic process
- spermatogenesis
- cell differentiation
- regulation of meiosis I
- proteasomal protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- proteasome core complex, alpha-subunit complex
- cytosol