PSMA8 Gene Summary [Human]
Predicted to be involved in meiotic cell cycle and proteasomal protein catabolic process. Located in extracellular exosome and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PSMA8 |
| Official Name | proteasome 20S subunit alpha 8 [Source:HGNC Symbol;Acc:HGNC:22985] |
| Ensembl ID | ENSG00000154611 |
| Bio databases IDs | |
| Aliases | proteasome 20S subunit alpha 8 |
| Synonyms | 2410072D24Rik, LOC100363246, LOC680840, proteasome 20S subunit alpha 8, proteasome 20S subunit α 8, proteasome subunit alpha 8, proteasome subunit α 8, PSMA7L, RGD1311659 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PSMA8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ntn_hydrolase
- Proteasome subunit A N-terminal signature
- peptidase
- Proteasome subunit A N-terminal signature Add an annotation
- proteasome endopeptidase complex, archaeal, alpha subunit
- protein binding
- Proteasome subunit
Pathways
Biological processes and signaling networks where the PSMA8 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PSMA8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- meiotic cell cycle
- proteasomal ubiquitin-dependent protein catabolic process
- spermatogenesis
- cell differentiation
- regulation of meiosis I
- proteasomal protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- proteasome core complex, alpha-subunit complex
- cytosol