Mcm2

Enables DNA replication origin binding activity; enzyme binding activity; and histone binding activity. Contributes to DNA helicase activity. Involved in DNA replication. Acts upstream of or within cellular response to interleukin-4 and nucleosome assembly. Located in nucleus. Part of MCM complex and nuclear origin of replication recognition complex. Is expressed in several structures, including central nervous system; future brain; inner cell mass; limb; and tooth. Human ortholog(s) of this gene implicated in Alzheimer's disease and autosomal dominant nonsyndromic deafness 70. Orthologous to human MCM2 (minichromosome maintenance complex component 2). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mcm2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Mcm2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Mcm2 gene, providing context for its role in the cell.