Crcp Gene Summary [Mouse]
Enables calcitonin gene-related peptide receptor activity. Acts upstream of or within neuropeptide signaling pathway. Located in acrosomal vesicle. Orthologous to human CRCP (CGRP receptor component). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Crcp |
| Official Name | calcitonin gene-related peptide-receptor component protein [Source:MGI Symbol;Acc:MGI:1100818] |
| Ensembl ID | ENSMUSG00000025532 |
| Bio databases IDs | |
| Aliases | calcitonin gene-related peptide-receptor component protein |
| Synonyms | C17, calcitonin gene-related peptide-receptor component protein, CGRP-RCP, CGRP receptor component, POLR3I, POLR3J, RCP, RCP9, RPC9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Crcp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcitonin gene-related polypeptide receptor
- DNA-directed RNA-polymerase II subunit
- DNA-directed RNA polymerase
- RNA polymerase Rpb4
- protein binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Crcp gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
regulates
- cyclic AMP
- DNA promoter
- DNA endogenous promoter
- CALCA
- CALC
- RNA polymerase iii
role in cell
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cytosol
- nucleoplasm
- acrosome
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Crcp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuropeptide signaling pathway
- transcription from RNA polymerase III promoter
- transcription initiation from RNA polymerase III promoter
- innate immune response
- defense response to virus
Cellular Component
Where in the cell the gene product is active
- DNA polymerase III complex
- acrosomal vesicle
- cytosol
- DNA-directed RNA polymerase III complex
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- protein binding
- DNA-directed RNA polymerase activity
- calcitonin gene-related polypeptide receptor activity