Ccnf Gene Summary [Mouse]
Predicted to enable anaphase-promoting complex binding activity and cyclin-dependent protein serine/threonine kinase regulator activity. Acts upstream of or within negative regulation of centrosome duplication; placenta development; and re-entry into mitotic cell cycle. Predicted to be located in cell junction; centriole; and centrosome. Predicted to be part of SCF ubiquitin ligase complex and cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Is expressed in liver lobe; midbrain ventricular layer; and telencephalon. Orthologous to human CCNF (cyclin F). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccnf |
| Official Name | cyclin F [Source:MGI Symbol;Acc:MGI:102551] |
| Ensembl ID | ENSMUSG00000072082 |
| Bio databases IDs | |
| Aliases | cyclin F |
| Synonyms | CycF, CYCLIN F, FBX1, FBXO1, FTDALS5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ccnf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain
- binding protein
- F-box domain superfamily
- Cyclin box fold superfamily
- F-box-like
- Cyclin, N-terminal domain
- protein binding
- domain present in cyclins, TFIIB and Retinoblastoma
Pathways
Biological processes and signaling networks where the Ccnf gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- hepatocellular carcinoma
- breast cancer
- organismal death
- psoriasis
- frontotemporal dementia and/or amyotrophic lateral sclerosis type 5
- breast carcinoma
- colon adenocarcinoma
- colon epithelial cancer
role in cell
- apoptosis
- proliferation
- ubiquitination in
- binding in
- fragmentation
- quantity
- cell cycle progression
- lagging
- duplication
- focus formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cell junction
- centrosome
- centriole
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ccnf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- re-entry into mitotic cell cycle
- cell division
- negative regulation of centrosome duplication
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- regulation of cell cycle
- placenta development
- protein ubiquitination
- regulation of cyclin-dependent protein kinase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- perinuclear region of cytoplasm
- cytoplasm
- centriole
- cyclin-dependent protein kinase holoenzyme complex
- cell junction
- cytosol
- SCF ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- cyclin-dependent protein kinase regulator activity
- protein binding
- anaphase-promoting complex binding