Dgki Gene Summary [Mouse]
Enables ATP-dependent diacylglycerol kinase activity; GTPase inhibitor activity; and small GTPase binding activity. Involved in presynaptic modulation of chemical synaptic transmission. Acts upstream of or within several processes, including chemical synaptic transmission; habituation; and modulation of chemical synaptic transmission. Located in perinuclear region of cytoplasm. Part of guanyl-nucleotide exchange factor complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in cerebral cortex; cerebral cortex mantle layer; and cerebral cortex marginal layer. Orthologous to human DGKI (diacylglycerol kinase iota). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dgki |
| Official Name | diacylglycerol kinase, iota [Source:MGI Symbol;Acc:MGI:2443430] |
| Ensembl ID | ENSMUSG00000038665 |
| Bio databases IDs | |
| Aliases | diacylglycerol kinase, iota |
| Synonyms | 6430604M11Rik, C130010K08RIK, DGK-IOTA, DGK-ι, diacylglycerol kinase iota, diacylglycerol kinase, iota, diacylglycerol kinase ι, diacylglycerol kinase, ι, LOC100128727, LOC500082, rDGKi-3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dgki often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ankyrin repeats (many copies)
- diacylglycerol kinase
- Ankyrin repeats (3 copies)
- enzyme binding
- protein binding
- Ankyrin repeat
- Diacylglycerol kinase catalytic domain (presumed)
- kinase
- GTPase inhibitor
- Diacylglycerol kinase accessory domain
- protein kinase C conserved region 1 (C1 domain) superfamily
- Diacylglycerol kinase catalytic domain
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- osteoarthritis
- major depression
- prostate cancer
- schizophrenia
- cognitive impairment
- hip or knee osteoarthritis
- thyroid carcinoma
- epithelial thyroid cancer
- insomnia
role in cell
- morphology
- activation
- long term synaptic depression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- glutaminergic synapse
- cell periphery
- perinuclear region
- Nucleus
- Plasma Membrane
- cytosol
- synaptic membrane
- dendritic spines
- synaptic vesicles
- synapse
- perikaryon
- axons
- dendrites
- postsynaptic density
- axon terminals
- excitatory synapses
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dgki gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein kinase C-activating G-protein coupled receptor signaling pathway
- platelet activation
- intracellular signal transduction
- phosphatidic acid biosynthetic process
- lipid phosphorylation
- diacylglycerol metabolic process
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- synaptic membrane
- synapse
- plasma membrane
- nucleus
- cytoplasm
- dendritic spine
- membrane
- cytosol
- macromolecular complex
- synaptic vesicle membrane
- axon
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- diacylglycerol kinase activity