Prkcg Gene Summary [Mouse]
Enables calcium,diacylglycerol-dependent serine/threonine kinase activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of protein metabolic process; and response to morphine. Acts upstream of or within chemosensory behavior; regulation of phagocytosis; and synaptic signaling via neuropeptide. Located in several cellular components, including dendrite; postsynaptic density; and synaptic membrane. Is active in calyx of Held and presynaptic cytosol. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and hemolymphoid system gland. Used to study spinocerebellar ataxia type 14. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 14. Orthologous to human PRKCG (protein kinase C gamma). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Prkcg |
| Official Name | protein kinase C, gamma [Source:MGI Symbol;Acc:MGI:97597] |
| Ensembl ID | ENSMUSG00000078816 |
| Bio databases IDs | |
| Aliases | protein kinase C, gamma |
| Synonyms | KPCG, PKC, PKCC, PKCG, PKC-gamma, PKCI, PKCI(3), PKC-γ, Prkc, Prkcc, protein kinase C gamma, protein kinase C, gamma, protein kinase C γ, protein kinase C, γ, RATPKCI, SCA14 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prkcg often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- protein kinase
- protein threonine/tyrosine kinase
- Protein kinase (unclassified specificity)
- regulatory domain
- Protein kinase C terminal domain
- Protein tyrosine and serine/threonine kinase
- catalytic domain
- V1 region
- protein binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- calcium dependent protein kinase C
- Protein Kinases, catalytic domain
- Extension to Ser/Thr-type protein kinases
- protein kinase C conserved region 1 (C1 domain) superfamily
- pseudosubstrate domain
- protein kinase C
- Tyrosine kinase, catalytic domain
- Protein kinase C conserved region 2 (CalB)
- C2 domain
- hydrophobic domain
Pathways
Biological processes and signaling networks where the Prkcg gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Apelin Endothelial Signaling Pathway
- CCR5 Signaling in Macrophages
- Cholecystokinin/Gastrin-mediated Signaling
- Corticotropin Releasing Hormone Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- ErbB4 Signaling
- Fc Epsilon RI Signaling
- fMLP Signaling in Neutrophils
- Growth Hormone Signaling
- Gαq Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- IL-3 Signaling
- Macropinocytosis Signaling
- Mechanisms of Viral Exit from Host Cells
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- NF-κB Activation by Viruses
- nNOS Signaling in Neurons
- Prolactin Signaling
- Thrombopoietin Signaling
- UVB-Induced MAPK Signaling
- UVC-Induced MAPK Signaling
- VDR/RXR Activation
- VEGF Family Ligand-Receptor Interactions
- Virus Entry via Endocytic Pathways
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pain
- neoplasia
- purkinje cell degeneration
- spinocerebellar ataxia 14
- epithelial cancer
- carcinoma of ampulla of Vater
- ampullary cancer
- ataxia
- colorectal cancer
- ovarian cancer
role in cell
- expression in
- migration
- differentiation
- cell death
- growth
- phosphorylation in
- proliferation
- apoptosis
- survival
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- membrane fraction
- cilia
- somatodendritic region
- perinuclear region
- cellular membrane
- cell cortex
- Nucleus
- Plasma Membrane
- intercellular junctions
- cytosol
- synaptic membrane
- synaptic vesicles
- synaptosomes
- cytoplasmic vesicles
- membrane rafts
- perikaryon
- axons
- dendrites
- postsynaptic density
- axon terminals
- lamellipodia
- apical processes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prkcg gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of response to food
- innervation
- negative regulation of protein catabolic process
- synaptic transmission
- response to morphine
- regulation of circadian rhythm
- protein phosphorylation
- chemosensory behavior
- response to toxin
- negative regulation of neuron apoptotic process
- learning or memory
- response to pain
- rhythmic process
- regulation of synaptic vesicle exocytosis
- long-term synaptic potentiation
- phosphorylation
- negative regulation of protein ubiquitination
- positive regulation of mismatch repair
- peptidyl-serine phosphorylation
- regulation of phagocytosis
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- dendrite
- nucleus
- postsynaptic density
- cell-cell junction
- perinuclear region of cytoplasm
- cytosol
- synaptic membrane
- plasma membrane
- calyx of Held
Molecular Function
What the gene product does at the molecular level
- ATP binding
- zinc ion binding
- protein serine/threonine/tyrosine kinase activity
- protein binding
- protein kinase activity
- protein serine/threonine kinase activity
- calcium-dependent protein kinase C activity
- protein kinase C activity