Dlg2 Gene Summary [Mouse]
A structural constituent of postsynaptic density. Involved in several processes, including axo-dendritic protein transport; clustering of voltage-gated potassium channels; and neurotransmitter receptor localization to postsynaptic specialization membrane. Acts upstream of or within chemical synaptic transmission and sensory perception of pain. Located in several cellular components, including juxtaparanode region of axon; postsynaptic membrane; and synaptic vesicle membrane. Is active in axon initial segment and glutamatergic synapse. Is expressed in jaw bone; nervous system; and retina. Orthologous to human DLG2 (discs large MAGUK scaffold protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Dlg2 |
| Official Name | discs large MAGUK scaffold protein 2 [Source:MGI Symbol;Acc:MGI:1344351] |
| Ensembl ID | ENSMUSG00000052572 |
| Bio databases IDs | |
| Aliases | discs large MAGUK scaffold protein 2 |
| Synonyms | A330103J02Rik, B230218P12RIK, B330007M19Rik, Chapsyn-110, discs large MAGUK scaffold protein 2, Dlgh2, Gm1197, Gm21505, LOC108349816, PPP1R58, PSD-93 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dlg2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- L27_1
- protein phosphatase binding
- canonical PDZ domain
- protein binding
- PDZ domain
- PDZ-domain binding
- Src Homology 3 domain superfamily
- L27 domain
- kinase
- guanylate kinase
- Veli/LIN-7 binding domain
- kinase binding
- Polyubiquitination (PEST) N-terminal domain of MAGUK
- binding protein
- NK
- guanylate kinase-like domain
- structural molecule
- cpPDZ_Deg_HtrA-like
- PDZ-associated domain of NMDA receptors
Pathways
Biological processes and signaling networks where the Dlg2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- alcoholism
- osteoarthritis
- Parkinson disease
- cardiovascular disorder
- schizophrenia
- insomnia
- tinnitus
- non-insulin-dependent diabetes mellitus
- periodontitis
role in cell
- migration
- formation
- formation in
- morphology
- response by
- sprouting angiogenesis by
- disassembly in
- replication in
- clustering in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- postsynaptic density (PSD) fractions
- synaptic vesicle membrane
- glutaminergic synapse
- cell junction
- axon component
- Cytoplasm
- cellular membrane
- microtubules
- cytosol
- postsynaptic membrane
- synaptic membrane
- dendritic spines
- growth cone
- dendritic trees
- juxtaparanodes
- synaptosomes
- synapse
- smooth endoplasmatic reticulum
- membrane rafts
- perikaryon
- dendrites
- postsynaptic density
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dlg2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- embryo development
- establishment or maintenance of epithelial cell apical/basal polarity
- GDP metabolic process
- synaptic transmission
- GMP metabolic process
- receptor clustering
- receptor localization to synapse
- cellular response to potassium ion
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- adherens junction
- voltage-gated potassium channel complex
- membrane
- cytosol
- neuromuscular junction
- juxtaparanode region of axon
- perikaryon
- basolateral plasma membrane
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- ionotropic glutamate receptor binding
- protein binding
- guanylate kinase activity
- kinase binding