Dlg3

Enables ubiquitin protein ligase binding activity. Involved in regulation of postsynaptic membrane neurotransmitter receptor levels. Acts upstream of or within establishment of planar polarity and establishment or maintenance of epithelial cell apical/basal polarity. Located in bicellular tight junction; cytoplasm; and plasma membrane. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse. Is expressed in central nervous system and retina. Used to study non-syndromic X-linked intellectual disability. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 90. Orthologous to human DLG3 (discs large MAGUK scaffold protein 3). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dlg3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Dlg3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Dlg3 gene, providing context for its role in the cell.