Prkca Gene Summary [Mouse]
Enables calcium,diacylglycerol-dependent serine/threonine kinase activity; integrin binding activity; and lipid binding activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of cytokine production involved in inflammatory response; and positive regulation of bone resorption. Acts upstream of or within several processes, including induction of positive chemotaxis; negative regulation of signal transduction; and regulation of protein phosphorylation. Located in several cellular components, including cone photoreceptor outer segment; intercalated disc; and ooplasm. Part of alphav-beta3 integrin-PKCalpha complex. Is active in calyx of Held and presynaptic cytosol. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; high grade glioma (multiple); large cell carcinoma; and reproductive organ cancer (multiple). Orthologous to human PRKCA (protein kinase C alpha). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prkca |
| Official Name | protein kinase C, alpha [Source:MGI Symbol;Acc:MGI:97595] |
| Ensembl ID | ENSMUSG00000050965 |
| Bio databases IDs | |
| Aliases | protein kinase C, alpha |
| Synonyms | AAG6, AI875142, LOC146784, PKCA, PKC-alpha, PKCI+/-, PKC-α, PKRCA, PRKACA, protein kinase C alpha, protein kinase C, alpha, protein kinase C α, protein kinase C, α, α-protein kinase C |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prkca often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- protein kinase
- regulatory domain
- ATP-binding domain
- V1 region
- C1A domain
- enzyme
- calcium binding loop
- Turn motif
- Protein kinase domain
- cytoplasmic domain
- Extension to Ser/Thr-type protein kinases
- protein kinase C conserved region 1 (C1 domain) superfamily
- protein kinase C
- Tyrosine kinase, catalytic domain
- V2 domain
- C2 domain
- Protein kinase (unclassified specificity)
- lipid binding
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- enzyme binding
- protein binding
- receptor binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- calcium dependent protein kinase C
- Protein Kinases, catalytic domain
- diacylglycerol binding
- pseudosubstrate domain
- integrin binding
- C1B domain
- hinge domain
- Protein kinase C conserved region 2 (CalB)
- hydrophobic domain
Pathways
Biological processes and signaling networks where the Prkca gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Caveolar-mediated Endocytosis Signaling
- Chemokine Signaling
- Corticotropin Releasing Hormone Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- EGF Signaling
- Fc Epsilon RI Signaling
- FGF Signaling
- Glioma Signaling
- Growth Hormone Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- IL-3 Signaling
- Macropinocytosis Signaling
- Mechanisms of Viral Exit from Host Cells
- NF-κB Activation by Viruses
- nNOS Signaling in Neurons
- Prolactin Signaling
- Role of MAPK Signaling in the Pathogenesis of Influenza
- Thrombopoietin Signaling
- UVB-Induced MAPK Signaling
- UVC-Induced MAPK Signaling
- VDR/RXR Activation
- VEGF Family Ligand-Receptor Interactions
- VEGF Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- neoplasia
- epithelial neoplasia
- papillomatosis
- benign neoplasia
- non-small cell lung cancer
- non-small cell lung carcinoma
- asthma
- lung cancer
- organismal death
role in cell
- proliferation
- expression in
- activation
- accumulation in
- migration
- cellular infiltration by
- phosphorylation in
- activation in
- phagocytosis
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- soluble fraction
- detergent-insoluble fractions
- membrane/cytoplasmic fraction
- membrane fraction
- mitochondrial fraction
- cytoskeleton
- cell periphery
- apical compartment
- perinuclear region
- cellular membrane
- focal adhesions
- Nucleus
- Plasma Membrane
- basal bodies
- Endoplasmic Reticulum
- Mitochondria
- intercellular junctions
- cytosol
- endoplasmic reticulum membrane
- caveolae
- nucleoplasm
- perinuclear space
- growth cone
- nerve ending
- synaptosomes
- synapse
- matrix vesicles
- photoreceptor outer segments
- sarcolemma
- perikaryon
- axons
- dendrites
- axon terminals
- parallel fiber
- detergent-soluble fraction
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prkca gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic nuclear envelope disassembly
- negative regulation of glial cell apoptotic process
- regulation of platelet aggregation
- apoptotic signaling pathway
- regulation of mRNA stability
- cell adhesion
- positive regulation of cell adhesion
- protein phosphorylation
- post-translational protein modification
- positive regulation of angiogenesis
- desmosome assembly
- chromatin remodeling
- angiogenesis
- positive regulation of macrophage differentiation
- positive regulation of cardiac muscle hypertrophy
- positive regulation of endothelial cell migration
- intracellular signal transduction
- positive regulation of mitotic cell cycle
- positive regulation of blood vessel endothelial cell migration
- positive regulation of dense core granule biogenesis
- positive regulation of bone resorption
- positive regulation of ERK1 and ERK2 cascade
- response to interleukin-1
- positive regulation of endothelial cell proliferation
- peptidyl-serine phosphorylation
- positive regulation of lipopolysaccharide-mediated signaling pathway
- peptidyl-threonine phosphorylation
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- mitochondrial membrane
- cilium basal body
- cytoplasm
- mitochondrion
- alphav-beta3 integrin-PKCalpha complex
- cytosol
- endoplasmic reticulum
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- zinc ion binding
- protein binding
- protein kinase activity
- integrin binding
- protein serine/threonine kinase activity
- calcium-dependent protein kinase C activity
- histone kinase activity (H3-T6 specific)
- enzyme binding
- protein kinase C activity