Nfyb Gene Summary [Mouse]
Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Contributes to transcription cis-regulatory region binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor and positive regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including alimentary system; branchial arch; early conceptus; genitourinary system; and nervous system. Orthologous to human NFYB (nuclear transcription factor Y subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nfyb |
| Official Name | nuclear transcription factor-Y beta [Source:MGI Symbol;Acc:MGI:97317] |
| Ensembl ID | ENSMUSG00000020248 |
| Bio databases IDs | |
| Aliases | nuclear transcription factor-Y beta |
| Synonyms | CBF-A, CBF-B, HAP3, Nfya, nuclear transcription factor-Y beta, nuclear transcription factor Y subunit beta, nuclear transcription factor Y subunit β, nuclear transcription factor-Y β |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nfyb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone-fold domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- transcription factor binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- histone fold domain (HFD) superfamily
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- binding protein
- double-stranded DNA binding
- transcription factor activity
Pathways
Biological processes and signaling networks where the Nfyb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dysferlinopathy
- early onset gastric cancer
- organismal death
role in cell
- inhibition in
- expression in
- production in
- differentiation
- epithelial-mesenchymal transition
- transactivation in
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nfyb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- CCAAT-binding factor complex
- nucleus
- protein-DNA complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- protein heterodimerization activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity