Mmrn2 Gene Summary [Mouse]
Predicted to enable receptor ligand activity. Predicted to be an extracellular matrix structural constituent. Involved in cell migration involved in sprouting angiogenesis; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; and positive regulation of defense response to bacterium. Located in basement membrane. Is expressed in several structures, including cardiovascular system; early conceptus; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human MMRN2 (multimerin 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mmrn2 |
| Official Name | multimerin 2 [Source:MGI Symbol;Acc:MGI:2385618] |
| Ensembl ID | ENSMUSG00000041445 |
| Bio databases IDs | |
| Aliases | multimerin 2 |
| Synonyms | EMILIN-3, ENDOGLYX-1, multimerin 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mmrn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
- EMI domain
- receptor agonist activity
- protein binding
- C1q domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- extracellular matrix
- plasma
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mmrn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- negative regulation of vascular endothelial growth factor receptor signaling pathway
- cell migration involved in sprouting angiogenesis
- cell adhesion
- negative regulation of cell migration involved in sprouting angiogenesis
- negative regulation of cell migration
- positive regulation of defense response to bacterium
Cellular Component
Where in the cell the gene product is active
- basement membrane
- extracellular space
- extracellular vesicular exosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- extracellular matrix structural constituent